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Mitigation of inhibitors generated in the pre-treatment of vegetal biomass: technical-economic-environmental impact of different processing routes in the biorefinery

Grant number: 17/21173-1
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): April 01, 2018
Effective date (End): April 30, 2021
Field of knowledge:Engineering - Chemical Engineering - Chemical Process Industries
Principal researcher:Cristiane Sanchez Farinas
Grantee:Ariane Silveira Sbrice Pinto
Home Institution: Embrapa Instrumentação Agropecuária. Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA). Ministério da Agricultura, Pecuária e Abastecimento (Brasil). São Carlos , SP, Brazil
Associated research grant:16/10636-8 - From the cell factory to the Biodiesel-Bioethanol integrated biorefinery: a systems approach applied to complex problems in micro and macroscales, AP.BIOEN.TEM


The implantation of large-scale conversion of lignocellulosic biomass into biofuels and other bioproducts still has technological challenges related to the pretreatment process. At this step, high amounts of inhibitors of the subsequent biochemical reactions are released, notably phenolic compounds and furaldehydes. Hence, strategies to mitigate and/or block the negative effect of the inhibitors from the pretreatment of lignocellulosic material are essential to reduce costs related to enzyme replacement and low fermentation efficiency in the production of bioethanol within the the biorefineries. The inclusion of a biomass washing step and/or the use of additives to reduce the unproductive adsorption of enzymes in the residual lignin are alternatives to optimize the production of second generation (2G) ethanol. However, there are no studies that compare the technical-economic-environmental impact of these alternatives in the bioprocesses of an integrated biorefinery. In this context, the innovation of this doctorate concerns the evaluation of the techno-economic impact on the production of bioethanol in biorefineries in light of the mitigation of the negative effect of inhibitors through different strategies, such as washing and using additives. The reverse analysis of the techno-economical viability of processes based on simulations in EMSO® software was developed by LaDAbio will be applied in this doctorate, since it allows to define performance goals, as well as providing support for the analysis of environmental impacts within the context of an integrated biorefinery biodiesel-bioethanol 1G-2G. Therefore, this project is linked to the thematic project of the BIOEN/FAPESP program: "From the cellular plant to the integrated biorefinery biodiesel-bioethanol: a systemic approach applied to complex problems in micro and macro scales" (proc. 2016/ 10636-8), in the research line 1. The results of this doctorate will define the best inhibitor mitigation strategy that corresponds to the techno-economic viability of the biorefinery with the discussion of environmental sustainability versus water consumption. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PINTO, ARIANE S. S.; ELIAS, ANDREW M.; FURLAN, FELIPE F.; RIBEIRO, MARCELO P. A.; GIORDANO, ROBERTO C.; FARINAS, CRISTIANE S. Techno-Economic Feasibility of Biomass Washing in 1G2G Sugarcane Biorefineries. BioEnergy Research, JAN 2021. Web of Science Citations: 0.

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