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Association between body composition and brown adipose tissue activity in human adults

Grant number: 17/22586-8
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): May 01, 2018
Effective date (End): April 30, 2019
Field of knowledge:Health Sciences - Nutrition
Principal Investigator:Milena Monfort Pires
Grantee:Giulianna Regeni Silva
Host Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:13/07607-8 - OCRC - Obesity and Comorbidities Research Center, AP.CEPID


The increase in the prevalence of overweight and obesity in Brazil and in the world has raised the search for therapeutic measures in order to combat it. Brown adipose tissue, rediscovered less than a decade ago, plays an important role in energy homeostasis and there is evidence that its activity is inversely associated with obesity. Few studies have evaluated the association between body composition and brown adipose tissue, and there is practically no study with this objective in the Brazilian population. The objective of the study is to investigate the association between body composition, assessed by Dual-energy X-ray absorptiometry (DXA), and brown adipose tissue activity (evaluated by PET / MRI) of obese and lean humans. This study has a cross-sectional design and it is a part of an open clinical trial lasting four weeks. Obese and lean participants are evaluated for brown adipose tissue (by FDG PET / MRI scan), body composition (DXA), dietary intake and physical activity. Data will be expressed as mean and standard deviation and the association between variables will be evaluated by correlation. Linear and logistic regression analyzes will also be performed to evaluate the association between the variables adjusting for possible confounding factors. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MONFORT-PIRES, M.; SILVA, G. R.; DADSON, P.; NOGUEIRA, G. A.; U-DIN, M.; VIRTANEN, K. A.; VELLOSO, L. A.. Brown adipose tissue content of triglycerides, but not SUV, is associated with cardiovascular risk markers in volunteers from a tropical region. Diabetologia, v. 65, n. SUPPL 1, p. 1-pg., . (19/02055-3, 16/10616-7, 17/22586-8)
MONFORT-PIRES, MILENA; REGENI-SILVA, GIULIANNA; DADSON, PRINCE; NOGUEIRA, GUILHERME A.; U-DIN, MUEEZ; FERREIRA, SANDRA R. G.; SAPIENZA, MARCELO TATIT; VIRTANEN, KIRSI A.; VELLOSO, LICIO A.. Brown fat triglyceride content is associated with cardiovascular risk markers in adults from a tropical region. FRONTIERS IN ENDOCRINOLOGY, v. 13, p. 13-pg., . (17/22586-8, 19/02055-3, 13/07607-8, 18/05479-6, 16/10616-7)

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