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Preliminar studies and development of the sequential intramolecular Heck-Matsuda reaction using carbon dioxide

Grant number: 18/02945-6
Support Opportunities:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): March 01, 2018
Effective date (End): May 31, 2022
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Carlos Roque Duarte Correia
Grantee:Otto Daolio Koster
Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:14/25770-6 - New frontiers in cross-coupling reactions promoted by palladium: combining enantioselective catalysis, C-H activations, new materials and in flux reactions aiming at high efficiency and sustainability in synthetic processes, AP.TEM


Taking into account preliminary results from the laboratory of prof. Correia, we aiming at studying the sequential intramolecular Heck-Matsuda reaction using carbon dioxide in a new carbonylation process. Several studies are planned, including the reaction conditions which would allow the synthesis of the desired products in high yields and enantioselectivities, in route to the preparation of bioactive dihydrobenzofurans. Among the reaction conditions to be evaluated we can highlight the solvent in view of its influence for high conversion and enantioselectivity. The synthesis of the starting materials in an effective way will also be carefully evaluated, as many of these complex salts are chemically unstable. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DUARTE CHORRO, TOMAZ HENRIQUE; SCARPA DE SOUZA, EDSON LEONARDO; KOSTER, OTTO DAOLIO; POLO, ELLEN CHRISTINE; CARMONA, RAFAELA COSTA; MENEZES DA SILVA, VITOR HUGO; BATISTA JUNIOR, JOAO MARCOS; DUARTE CORREIA, CARLOS ROQUE. In Tandem Enantioselective Intramolecular Heck-Matsuda Reactions directly from Anilines. ADVANCED SYNTHESIS & CATALYSIS, v. 365, n. 2, p. 13-pg., . (13/07600-3, 18/16916-8, 19/25657-9, 19/22319-5, 14/25770-6, 18/00271-8, 17/18207-1, 18/02945-6)

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