Introduction: thiamine (B1 vitamin) is a vitamin that acts as coenzyme for several enzymatic complexes involved in carbohydrates metabolism. Recently, thiamine deficiency has been related to critical situations, such as septic shock. Aims: to evaluate the influence of thiamine supplementation on oxidative stress, energy metabolism and mortality in patients with septic shock admitted to the intensive care unit. Patients and Methods: this is a prospective, controlled, double-blind, randomized study that included 116 patients diagnosed with septic shock admitted to the intensive care units (UCI) of Hospital das Clínicas, Botucatu Medical School. Patients will be allocated into two groups: thiamine supplementation and placebo. Thiamine will be administered intravenously, 200mg every 12 hours, for 5 days or until discharge from the ICU. The placebo will be administered in equivalent volume by the same route and period. Blood samples will be collected before and 48 hours after supplementation and the samples will be used to determine thiamine concentration, carbonyl protein, lipid hydroperoxide, activity of antioxidants enzymes and energetic metabolism enzymes. The primary endpoint to be evaluated will be mortality and as secondary outcomes, mechanical ventilation, vasoactive drug use, ICU stay and hospital stay will be assessed.
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