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Genetic and biological characterization of Dengue virus, Zika virus and Chikungunya virusisolated in a prospective cohort in SJ Rio Preto, SP

Grant number: 15/14313-6
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): March 01, 2018
Effective date (End): January 31, 2021
Field of knowledge:Biological Sciences - Microbiology - Biology and Physiology of Microorganisms
Principal Investigator:Maurício Lacerda Nogueira
Grantee:Karina Rocha Dutra
Host Institution: Faculdade de Medicina de São José do Rio Preto (FAMERP). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São José do Rio Preto , SP, Brazil
Associated research grant:13/21719-3 - Epidemiological study of dengue (serotypes1-4) in a cohort of São José do Rio Preto, São Paulo, Brazil, during 2014-2018, AP.TEM


Dengue is one of the most important arbovirus diseases in the world. The Dengue virus belongs to the genus Flavivirus (family Flaviviridae) and has four genetically and antigenically distinct serotypes (DENV-1, DENV-2, DENV-3, DENV-4). The virus is transmitted by Aedes aegypti mosquitoes in tropical and subtropical areas in which climatic conditions favor the maintenance of the vectors. An increase in the genetic variability of the virus has been described, allowing characterize different genotypes and lineages within each serotype that may have significant differences in biological characteristics. To date, there is the deficit of broader studies correlating the epidemiology of the disease, genetic variability and interaction between virus and the host. Therefore, this work intendeds to evaluate the genetic and biological characteristics of Dengue virus samples isolated from patients followed in a prospective cohort study in São Jose do Rio Preto. In addition, in this study is intended to evaluate the incidence and prevalence of distinct serotypes, and, then to analyze phylogenetically the isolated viral strains in the municipality, to correlate genetic variability of viral strains with the multiplication rate, virulence, pathogenicity and to correlate them with the clinical and epidemiological features of patients.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
JAQUELINE GOES DE JESUS; KARINA ROCHA DUTRA; FLAVIA CRISTINA DA SILVA SALES; INGRA MORALES CLARO; ANA CAROLINA TERZIAN; DARLAN DA SILVA CANDIDO; SARAH C HILL; JULIEN THÉZÉ; CELESTE TORRES; TATIANA LANG DAGOSTINI; et al. Genomic detection of a virus lineage replacement event of dengue virus serotype 2 in Brazil, 2019. Memórias do Instituto Oswaldo Cruz, v. 115, . (15/12295-0, 16/01735-2, 18/14389-0, 13/21719-3, 15/14313-6)

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