Forensic toxicology analysis are applied in different contexts, like medico-legal investigation to determine cause of death; monitoring the use of drugs and alcohol by drivers; evaluating the fatal exposure to illicit drugs and antidoping control on sports. It aims different chemical compounds like ethanol, cocaine, cannabis, amphetamines, opiates and some medicines. Toxicological analysis can be applied on any biological tissue or fluid. However, blood is the only matrix that can reflect impairment on the moment of collection. The classic methodology for drug extraction from matrix requires a big volume of organic solvents, are time consuming and requires high sample manipulation. In the last few years the environmental appeal is growing and this forced the development of new methodology, called microextractions. These new methods require little quantity of solvent, are simple and effective. The most used techniques are the solid phase microextraction (SPME) and liquid phase microextraction (LPME). In the present study, we aim to develop and validate LPME methods for the detection of cocaine and biotransformation products, cannabinoids and amphetamines on blood samples with detection on gas chromatography-mass spectrometry. These methods could be used in the future in epidemiological projects aiming the identification of prevalence of drug use.
News published in Agência FAPESP Newsletter about the scholarship: