Rats submitted to Status epilepticus (SE) during development present behavioral changes typical of animal models of psychosis, which correlate with changes in synaptic plasticity between the hippocampus and the prefrontal cortex (CPF). Our hypothesis is that SE affects the connectivity of meso-cortico-limbic circuits, which may underlie psychiatric comorbidities observed in epilepsy. Our aim is to investigate how the induction of SE during development affects the communication between the hippocampus, the prefrontal cortex and the ventral tegmental area during the performance of behavioral tests related to psychosis and depression. These findings will be related to cognitive impairments and markers of epileptogenesis, such as interictal activity and the presence of spontaneous seizures. For this purpose, we will use electrophysiology and optogenetic stimulation techniques, allowing a better understanding of the relationship between epiletogenesis and cognitive impairment, as well as the association of psychiatric comorbidities with temporal lobe epilepsy.
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