Association of nutritional status with muscle function, functional capacity and quality of life in maintenance hemodialysis patients

Abstract

Individuals with chronic kidney disease (CKD) usually develop protein-energy malnutrition. With the initiation of dialysis therapy, they present a decrease in functional capacity, which results in quality of life decrease, increasing sedentary lifestyle, aggravating the situation of muscle mass and muscle function loss, chronic systemic inflammation and cardiovascular disease, which in turn, aggravate protein-energy malnutrition. This study aims to evaluate the association of nutritional status with muscle function, functional capacity and quality of life of hemodialysis patients. Methodology: This cross-sectional study will include individuals with CKD diagnosis who undergo hemodialysis at the Presidente Prudente Hospital for at least three months, aged 18 years or older. Individuals with stroke sequelae, amputations, and patients with catabolic diseases will not participate. Participants will be submitted to a single assessment of nutritional status, quality of life and functional capacity. Participants will be characterized for demographic, clinical, and laboratory data. To evaluate nutritional status, the Malnutrition Inflammation Score (MIS) will be used. Handgrip strength will be used to evaluate muscle function, and Short Physical Performance Battery will assess functional capacity. Quality of life will be assessed by the SF-36 Quality of Life Questionnaire. To evaluate the individual's physical activity level, the International Physical Activity Questionnaire (IPAQ), adapted to the Brazilian culture, will be used to classify them as very active, active, irregularly active and sedentary. Data will be expressed as mean ± standard deviation or median and first and third quartiles, and percentage in the case of frequencies. To verify the relationship of nutritional status with continuous variables will be used Pearson or Spearman correlation. The sample will be divided into three groups, according to MIS tertiles for comparison of parameters of muscular function, quality of life and level of physical activity. To determine the extent in which nutritional status is associated with parameters of muscle function, functional capacity and quality of life multiple regression analysis will be employed, with adjustments for sex, age, and other variables. (AU)