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Characterization of two proteases from Babesia bovis parasite and their relevance in host infection.

Grant number: 17/25609-9
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): March 01, 2018
Effective date (End): August 31, 2018
Field of knowledge:Biological Sciences - Biochemistry - Chemistry of Macromolecules
Principal researcher:Aparecida Sadae Tanaka
Grantee:Stephen Lu
Supervisor abroad: Monica Ofelia Jacobsen
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Research place: Instituto Nacional de Tecnología Agropecuaria (INTA), Argentina  
Associated to the scholarship:15/09268-1 - Characterization of two proteases from Babesia bovis parasite: Importance in the host infections., BP.DR

Abstract

The Rhicepicephalus microplus tick is the major bovine ectoparasite in the tropical and sub-tropical regions of the world and is responsible for several losses in the livestock production. Moreover the tick acts as vector for two bovine pathogens the protozoan Babesia and the bacteria Anaplasma, which can cause further cattle damage. Although the R. microplus-Babesia is considered one of the most relevant vector-parasite relations, little is known about the mechanisms underlying Babesia infection and survival in its hosts. In the recent year a great effort have been made in order to identify and characterize key molecules in protozoan life cycle, in special for the malaria etiological agent Plasmomdium falciparum, in which it was demonstrated the importance of proteases during parasite invasion and egress from host red blood cells. Likewise, in Babesia sp it was already demonstrated the relevance of surface molecules for erythrocyte adhesion, also cysteine and serine peptidases gene have been already found in B. bovis and B. bigemina genome and their role during parasite infection demonstrated. Taking all together the objective of this project is the functional characterization of two peptidases found in B. bovis genome, one cysteine and one subtilisin-like peptidase. This project will be carried in collaboration with Dra. Mônica Ofelia Jacobsen from the Instituto de Patologia - Centro de Investigacion en Ciencias Veterinarias y Agronomicas in the Instituto Nacional de Tecnologia Agropecuaria (INTA) in Buenos Aires, Argentina.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LU, STEPHEN; ASCENCIO, MARIANO E.; TORQUATO, RICARDO J. S.; FLORIN-CHRISTENSEN, MONICA; TANAKA, APARECIDA S.. Kinetic characterization of a novel cysteine peptidase from the protozoan Babesia bovis, a potential target for drug design. Biochimie, v. 179, p. 127-134, . (15/09268-1, 17/25609-9, 12/03657-8)
LU, STEPHEN; DA ROCHA, LETICIA A.; TORQUATO, RICARDO J. S.; VAZ JUNIOR, ITABAJARA DA SILVA; FLORIN-CHRISTENSEN, MONICA; TANAKA, APARECIDA S.. A novel type 1 cystatin involved in the regulation of Rhipicephalus microplus midgut cysteine proteases. TICKS AND TICK-BORNE DISEASES, v. 11, n. 3, . (15/09268-1, 12/03657-8, 17/25609-9)

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