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Role of biofilm in the pathogenesis of dermatophytosis and development of combat strategies

Grant number: 17/18388-6
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): February 01, 2018
Effective date (End): July 31, 2021
Field of knowledge:Health Sciences - Pharmacy
Principal Investigator:Maria José Soares Mendes Giannini
Grantee:Caroline Barcelos Costa Orlandi
Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

The biofilm formation by microorganisms and their potential damage to health have been gaining prominence in recent years once they are communities resistant to antimicrobials and adverse environmental conditions. The description of filamentous fungi, especially dermatophytes as able to survive in communities is recent and may be related to the long time treatment, resistance to some antifungal dugs and common relapses to this type mycosis, particularly in the case of onychomycosis. Although many factors are clarified, the pathogenesis of these fungal infections has not yet been completely unraveled and knowledge of the involvement of biofilms in the pathogenesis mechanism is still incipient. On the other hand, it is necessary to emphasize the importance of the search of new and effective molecules against these communities of microorganisms. These molecules must also have reduced toxicity, since higher concentrations are required to achieve resistance mechanisms and new targets of action. This project aims to study molecular mechanisms involved in biofilm formation by dermatophytes and to evaluate the potential of new drugs against these communities. It is intended to identify possible T. rubrum and T. mentagrophytes genes differentially expressed in the initial phase of development and maturation of the communities, comparing to differences in post-infection gene expression. In addition, studies will be performed in order to evolve a molecule derived from protocatecuic acid, with broad antifungal spectrum and potent against biofilms to an antifungal drug, through the incorporation to nanosystems and conducting biochemical and molecular tests to unveil its mechanism of action.

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Scientific publications (10)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VASO, CAROLINA ORLANDO; PANDOLFI, FABIANA; BILA, NIURA MADALENA; DE VITA, DANIELA; BORTOLAMI, MARTINA; SOARES MENDES-GIANNINI, MARIA JOSE; TUDINO, VALERIA; COSTI, ROBERTA; COSTA-ORLANDI, CAROLINE BARCELOS; FUSCO-ALMEIDA, ANA MARISA; et al. Synthesis and Evaluation of the Antifungal and Toxicological Activity of Nitrofuran Derivatives. PHARMACEUTICS, v. 14, n. 3, p. 19-pg., . (20/15586-4, 16/11836-0, 19/22188-8, 17/18388-6)
COSTA-ORLANDI, CAROLINE BARCELOS; SERAFIM-PINTO, ALINE; DA SILVA, PATRICIA BENTO; BILA, NIURA MADALENA; DE CARVALHO BONATTI, JEAN LUCAS; SCOTZONI, LILIANA; SINGULANI, JUNYA DE LACORTE; DOS SANTOS, CLAUDIA TAVARES; NAZARE, ANA CAROLINA; CHORILLI, MARLUS; et al. Incorporation of Nonyl 3,4-Dihydroxybenzoate Into Nanostructured Lipid Systems: Effective Alternative for Maintaining Anti-Dermatophytic and Antibiofilm Activities and Reducing Toxicity at High Concentrations. FRONTIERS IN MICROBIOLOGY, v. 11, . (18/02785-9, 17/18388-6)
GONCALVES, LARISSA NAIARA CARVALHO; COSTA-ORLANDI, CAROLINE BARCELOS; BILA, NIURA MADALENA; VASO, CAROLINA ORLANDO; DA SILVA, ROSANGELA APARECIDA MORAES; MENDES-GIANNINI, MARIA JOSE SOARES; TAYLOR, MARIA LUCIA; FUSCO-ALMEIDA, ANA MARISA. Biofilm Formation byHistoplasma capsulatumin Different Culture Media and Oxygen Atmospheres. FRONTIERS IN MICROBIOLOGY, v. 11, . (17/18388-6, 19/22188-8)
DA SILVA, V, THAINA; DE BARROS, NATAN R.; COSTA-ORLANDI, CAROLINE B.; TANAKA, JEAN L.; MORO, LINCOLN G.; PEGORIN, GIOVANA S.; OLIVEIRA, KASSANDRA S. M.; MENDES-GIANINNI, MARIA J. S.; FUSCO-ALMEIDA, ARIA M.; HERCULANO, RONDINELLI D.. Voriconazole-natural latex dressings for treating infected Candida spp. skin ulcers. FUTURE MICROBIOLOGY, v. 15, n. 15, p. 1439-1452, . (17/19603-8, 17/18388-6)
COSTA-ORLANDI, CAROLINE BARCELOS; MARTINEZ, LUIS R.; BILA, NIURA MADALENA; FRIEDMAN, JOEL M.; FRIEDMAN, ADAM J.; MENDES-GIANNINI, MARIA JOSE S.; NOSANCHUK, JOSHUA D.. Nitric Oxide-Releasing Nanoparticles Are Similar to Efinaconazole in Their Capacity to Eradicate Trichophyton rubrum Biofilms. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, v. 11, . (18/02785-9, 17/18388-6, 19/22188-8)
GARCIA, LETICIA MORAIS; COSTA-ORLANDI, CAROLINE BARCELOS; BILA, NIURA MADALENA; VASO, CAROLINA ORLANDO; GONCALVES, LARISSA NAIARA CARVALHO; FUSCO-ALMEIDA, ANA MARISA; MENDES-GIANNINI, MARIA JOSE SOARES. A Two-Way Road: Antagonistic Interaction Between Dual-Species Biofilms Formed byCandida albicans/Candida parapsilosisandTrichophyton rubrum. FRONTIERS IN MICROBIOLOGY, v. 11, . (18/02785-9, 17/18388-6, 19/22188-8)
TANAKA, JEAN LUCAS; COSTA-ORLANDI, CAROLINE BARCELOS; BURD, BETINA SAYEG; PEGORIN, GIOVANA SANT'ANA; DA SILVA, THAINA VENANCIO; GUERRA, NAYRIM BRIZUELA; SOARES MENDES-GIANNINI, MARIA JOSE; FUSCO-ALMEIDA, ANA MARISA; HERCULANO, RONDINELLI DONIZETTI; DE BARROS, NATAN ROBERTO. Natural rubber dressing loaded with silver sulfadiazine for the treatment of burn wounds infected with Candida spp.. International Journal of Biological Macromolecules, v. 189, p. 597-606, . (17/19603-8, 11/17411-8, 17/18388-6, 14/17526-8)
BILA, NIURA MADALENA; COSTA-ORLANDI, CAROLINE BARCELOS; VASO, CAROLINA ORLANDO; BONATTI, JEAN LUCAS CARVALHO; DE ASSIS, LETICIA RIBEIRO; REGASINI, LUIS OCTAVIO; FONTANA, CARLA RAQUEL; FUSCO-ALMEIDA, ANA MARISA; MENDES-GIANNINI, MARIA JOSE SOARES. 2-Hydroxychalcone as a Potent Compound and Photosensitizer Against Dermatophyte Biofilms. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, v. 11, . (18/02785-9, 19/22188-8, 20/15586-4, 17/18388-6)
COSTA-ORLANDI, CAROLINE B.; BILA, NIURA M.; BONATTI, JEAN LUCAS C.; VASO, CAROLINA O.; SANTOS, MARIANA B.; POLAQUINI, CARLOS R.; BIASIOLI, MARIANA M. SANTONI M.; HERCULANO, RONDINELLI D.; REGASINI, LUIS O.; FUSCO-ALMEIDA, ANA MARISA; et al. Membranolytic Activity Profile of Nonyl 3,4-Dihydroxybenzoate: A New Anti-Biofilm Compound for the Treatment of Dermatophytosis. PHARMACEUTICS, v. 15, n. 5, p. 19-pg., . (17/18388-6, 19/22188-8, 18/02785-9, 20/15586-4)
VASO, CAROLINA ORLANDO; BILA, NIURA MADALENA; PANDOLFI, FABIANA; DE VITA, DANIELA; BORTOLAMI, MARTINA; CARVALHO BONATTI, JEAN LUCAS; DE MORAES SILVA, ROSANGELA APARECIDA; CARVALHO GONCALVES, LARISSA NAIARA; TUDINO, VALERIA; COSTI, ROBERTA; et al. Evaluation of the Anti-Histoplasma capsulatum Activity of Indole and Nitrofuran Derivatives and Their Pharmacological Safety in Three-Dimensional Cell Cultures. PHARMACEUTICS, v. 14, n. 5, p. 23-pg., . (20/15586-4, 19/22188-8, 18/02785-9, 17/18388-6, 16/11836-0)

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