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Evaluation of reactivity of cavernous smooth muscle in rats submitted to acute alteration of blood flow through the aortocaval fistula model

Grant number: 17/20695-4
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2017
Effective date (End): July 31, 2018
Field of knowledge:Biological Sciences - Pharmacology - Cardiorenal Pharmacology
Principal researcher:Mário Angelo Claudino
Grantee:Douglas Rafael Andrade
Home Institution: Universidade São Francisco (USF). Campus Bragança Paulista. Bragança Paulista , SP, Brazil
Associated research grant:11/21095-4 - Morphofunctional and molecular study of erectile function and lower urinary tract in rats with chronic heart failure: evaluation of the NO-sGC-cGMP signaling pathway, AP.JP


Erectile dysfunction (ED) is characterized as the inability to obtain or maintain a penile erection suitable for satisfactory sexual activity. Studies have demonstrated a strong association between ischemic heart disease and ED. Epidemiological studies indicate that 70% of patients with coronary artery disease have symptoms of ED. Both ED and ischemic heart disease share common risk factors, such as hypertension, dyslipidemia, diabetes mellitus and smoking, which are associated with dysfunction of the autonomic nervous system, as well as alterations in important signaling pathways that control the tone of the heart. Smooth musculature, redox cellular balance and nitric oxide (NO) bioavailability. Erectile function depends on the integrity of nerve structures and endothelium, since these are important due to the release of NO from these sources and consequent increase of intracellular cGMP. Therefore, changes in the NO-cGMP signaling pathway result in impaired erectile function. It is known that cardiovascular diseases (CVD) are associated with acute changes in blood flow, but the erectile function impairment in these situations is little elucidated. Therefore, the understanding of the disorders that may compromise this function may help in the understanding of several pathophysiological processes, as well as to establish possible pharmacological targets and new therapeutic proposals for the approach of erectile dysfunction associated with cardiovascular diseases. (AU)

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