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Micro-CT evaluation of caprine demineralized bone matrix (MOD) on bone healing in rabbits

Grant number: 17/09563-9
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): December 01, 2017
Effective date (End): February 28, 2019
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
Principal Investigator:Bruno Watanabe Minto
Grantee:Felipe Rocha dos Santos
Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil


Bone grafting has been extensively studied and used in dentistry, orthopedics and neurosurgery, in human and veterinary medicine. Autologous bone graft is the gold standard method, however, it has limitations such as donor site morbidity, iatrogenic fractures and availability for harvest. The demineralized bone matrix presents characteristics such as osteoinduction and osteoconduction, and can be stored for long periods, highlighting it as a promising bio-graft in the repair of bone defects. Due to the increasing demand for effective bone substitutes, availability of caprine bones and lack of studies, the purpose of this study was to evaluate the behavior of the caprine bone matrix demineralized as xenograft in rabbits. 30 adult New Zealand White Rabbits will be used. A 6mm proximal monocortical circular tibial bone defect will be created bilaterally. The left defect will be filled with caprine demineralized bone matrix and the right one will be the control. After 15, 30, 60, 90 and 120 days, 6 animals will be euthanized and evaluated by computerized helical microtomography, analyzing trabecular filling pattern, bone ingrowth, graft resorption rate and osseointegration. (AU)

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SANTOS, Felipe Rocha dos. Caprine demineralized bone matrix (MODc) in the repair of non-critical bone defects in rabbit tibia. 2019. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Ciências Agrárias e Veterinárias. Jaboticabal Jaboticabal.

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