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Study of macrophage modulation by extracellular vesicles of Sporothrix brasiliensis

Grant number: 17/19916-6
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2017
Effective date (End): November 30, 2018
Field of knowledge:Biological Sciences - Microbiology - Applied Microbiology
Principal Investigator:Karen Spadari Ferreira
Grantee:Gabriela Ferrari Rugani
Host Institution: Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF). Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Diadema , SP, Brazil


Sporotrichosis is an emerging mycosis that can affect the subcutaneous tissue, lymphatic system and other organs in humans and animals. It is a disease caused by a complex of at least four species and one of them is S. brasiliensis. Some fungi are able to release extracellular vesicles (VEs) that influence the immune response of the host. Macrophages are important phagocytic cells, therefore, study their interaction with these VEs of S brasiliensis contribute to understanding the pathogenesis of the disease, to seek new forms of therapy and diagnosis. (AU)

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