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Effect of the combination of treatments with casein phosphorus-amorphous calcium phosphate and sodium trimetaphosphate on the remineralization of caries lesions: an in vitro study

Grant number: 17/21018-6
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2017
Effective date (End): November 30, 2018
Field of knowledge:Health Sciences - Dentistry - Pediatric Dentistry
Principal Investigator:Alberto Carlos Botazzo Delbem
Grantee:Giovana Dornelas Azevedo Romero
Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil


The aim of the present study was to evaluate whether the association of fluoride-treated and supplemented with sodium trimetaphosphate (TMP) and amorphous calcium casephosphate (CPP-ACP) phosphotype (MI Paste Plus®) may increase the remineralization of lesions of caries. Bovine enamel blocks (4 mm × 4 mm, n = 72) will have their enamel surface polished to determine the initial surface hardness (HS). After they will be submitted to the induction of artificial caries lesions and the post-demineralization hardness (SH1) will be determined. The experimental design will be randomized and the blocks divided into 6 treatment groups (n = 12): 1) Dentifrice without F (Placebo); 2) Dentifrice with 1100 ppm F (1100F), 3) Dentifrice with 1100 ppm F associated with MI Paste Plus® (1100F / MI Paste Plus®), 4) Dentifrice with 1100 ppm F + 3% TMP (1100F/TMP) 5) MI Paste Plus® and 6) Dentifrice with 1100 ppm F + 3% TMP associated with MI Paste Plus® (1100F / TMP / MI Paste Plus®). The blocks will be submitted to 6 pH cycling for 6 days. For all groups treatments will be performed 2x/day for 1 minute, except for group 5, which after treatment with 1100F/TMP, will be applied MI Paste Plus®/3 minutes. The final surface hardness (SH2) will be determined for the calculation of the surface hardness recovery percentage (%SHR). The data will be submitted to the tests of normality and homogeneity to use the statistical test most appropriate to the data distribution. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CASTRO GONCALVES, FRANCYENNE MAIRA; BOTAZZO DELBEM, ALBERTO CARLOS; GOMES, LEONARDO FERNANDES; EMERENCIANO, NAYARA GONCALVES; PESSAN, JULIANO PELIM; AZEVEDO ROMERO, GIOVANA DORNELAS; CANNON, MARK L.; DANELON, MARCELLE. Effect of fluoride, casein phosphopeptide-amorphous calcium phosphate and sodium trimetaphosphate combination treatment on the remineralization of caries lesions: An in vitro study. ARCHIVES OF ORAL BIOLOGY, v. 122, . (20/03506-6, 17/21018-6, 18/24761-4)

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