Klebsiella pneumoniae is recognised as an urgent problem of public health worldwide, where the emergence and dissemination of multidrug-resistant (MDR) lineages has been associated with endemic clones producing hospital outbreaks and community-acquired infections. In this regard, K. pneumoniae clonal complex (CC) 258 (comprising STs 258, 11, 340, 437 and closely related variants) has been related with dissemination of the KPC-2 carbapenemase. Mobilization of blaKPC-2 gene has been supported by the horizontal transfer of Tn4401-type transposon carried on conjugative plasmids that contribute to the global success of high-risk clones. In Brazil, the rapid expansion of a virulent and carbapenem-resistant K. pneumoniae ST11 international high-risk clone has been documented, being associated with remarkable morbidity and mortality rates. Moreover, the presence of strains belonging to CC258 has been identified in human, food-production animals, urban aquatic environmental and recreational waters in metropolitan areas. The present study aims to perform a comparative genomic analysis of strains belonging to CC258 in the human-animal-environment interface, in Brazil, with further KPC-2 plasmid characterization.
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