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Exploring the immunogenic potential of photodynamic therapy

Grant number: 17/23914-9
Support Opportunities:Scholarships abroad - Research Internship - Post-doctor
Effective date (Start): April 15, 2018
Effective date (End): April 14, 2019
Field of knowledge:Biological Sciences - Biochemistry - Molecular Biology
Principal Investigator:Leticia Labriola
Grantee:Ancély Ferreira dos Santos
Supervisor: Patrizia Agostinis
Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Research place: University of Leuven (KU Leuven), Belgium  
Associated to the scholarship:16/04676-7 - Photodynamic therapy to treat breast cancer: proof of concept pre-clinical studies, BP.PD


Concentered efforts have been made in recent years to develop therapies that are able to treat various types of cancer more effectively. A promising alternative treatment is photodynamic therapy (PDT), consisting in tissue destruction by visible light in the presence of a photosensitizer substance and oxygen. Previous results from our group have shown that PDT using methylene blue as a photosensitizer (MB-PDT) is able to selectively eliminate human breast tumor cells using in models in vitro of cells cultured in monolayer or in spheroids. Interestingly, triple negative breast cancer cells, the most aggressive ones, display the highest sensitivity when submitted to MB-PDT. However, the effectiveness of this therapy in stimulate a favorable immune response to eradicate the tumor remains an aspect of great relevance. An ideal cancer treatment should merge the direct cytotoxic action on tumor cells with potent immunostimulatory effects based on the recognition of molecular immunogenic determinants on dying cells by immune cells. Therefore, in the present project, we set out to collaborate with Dr. Patrizia Agostinis, an expert in research on mechanisms of therapy-induced cancer cell death, including PDT, working at the School of Medicine of the University of Leuven, to study the induction of molecular markers of immunogenic cell death in cancer cells induced by different PDT-mediated stresses. We intent to contribute to indicate PDT as an effective therapy for tumors that present particular cell death resistance mechanisms, displaying minimal side effects if compared to conventional cancer treatments.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DOS SANTOS, ANCELY F.; INAGUE, ALEX; ARINI, GABRIEL S.; TERRA, LETICIA F.; WAILEMANN, ROSANGELA A. M.; PIMENTEL, ANDRE C.; YOSHINAGA, MARCOS Y.; SILVA, RICARDO R.; SEVERINO, DIVINOMAR; DE ALMEIDA, DARIA RAQUEL Q.; et al. Distinct photo-oxidation-induced cell death pathways lead to selective killing of human breast cancer cells. CELL DEATH & DISEASE, v. 11, n. 12, . (19/09517-2, 17/13804-1, 19/05026-4, 16/04676-7, 17/23914-9, 17/18922-2, 17/03618-6, 15/02654-3, 13/07937-8)

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