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Study of the blood flow hemodynamics of the regional veins of the abdominal organs and its relation with macro and microcirculatory flows in sepsis

Grant number: 17/10523-1
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2017
Effective date (End): November 30, 2018
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Ivan Hong Jun Koh
Grantee:Ye Ram Kang
Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Associated research grant:11/20401-4 - Sepsis: integrating basic research and clinical research II, AP.TEM

Abstract

Sepsis is associated with potentially fatal organ dysfunction caused by a dysregulated immune response to infection and is leading the mortality in the ICUs of the world, and remains a disease without a therapeutic consensus because of its complexity. Current sepsis therapy is based primarily on antibiotic therapy, fluid therapy and vasopressors, based on hemodynamic parameters centered on arterial macrocirculation. Venous hemodynamics and microcirculation continue to be poorly explored in sepsis. The ongoing research on microhemodynamics in sepsis of this laboratory has shown that microvascular changes in sepsis begin in the venous part and later in the arterial system. Thus, in this project, we aimed to evaluate the venous hemodynamics of various territories in acute sepsis and to try to establish their correlation with arterial macrohemodynamics. For this purpose, rats will be submitted to severe sepsis by inoculation of E.coli 108 CFU / mL, and monitored for: Mean arterial pressure; Blood flow of the abdominal aorta, inferior vena cava, portal, renal, superior mesenteric and splenic via Transonic System TS420 transit-time perivascular flowmeter; Tissue perfusion of the terminal ileum, liver and kidney by BLF 21 laser Doppler flow meter; Microcirculation dynamics by Sidestream Dark Field Imaging (SDF), in the periods from T0 to T3 (hs). The results will be analyzed in order to elucidate the pattern of venous circulation during the acute phase of sepsis in order to better understand the hemodynamic dysfunction in the acute phase of sepsis. (AU)

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