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Development of polymer blends of latex-alginate and latex-collagen for tissue engineering application

Grant number: 17/02518-8
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): December 01, 2017
Effective date (End): May 31, 2020
Field of knowledge:Engineering - Biomedical Engineering - Bioengineering
Principal Investigator:Rondinelli Donizetti Herculano
Grantee:Natan Roberto de Barros
Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Associated research grant:16/01743-5 - The new gestational triad: hyperglycemia, urinary incontinence (UI) and biomolecular profile as a long-term predictor for UI: a prospective cohort study: translational research with biodevice with stem cells for muscle regeneration in diabetic rats, AP.TEM
Associated scholarship(s):18/11861-0 - Skin-on-a-chip model for drug treatment study, BE.EP.DR


The natural rubber latex extracted from rubber tree Hevea brasiliensis have shown promising results in biomedical applications where membranes produced from this material have been used as medical prostheses and grafts due to their biocompatibility characteristics, bone growth and natural stimulation to angiogenesis. According to the literature, no in vivo work showed degradation of the latex during the experimental period. Thus, the objective of this work is the development and characterization of natural latex membranes functionalized with alginate / collagen for tissue engineering applications. In this way, it is expected to make possible the use of these new membranes based on natural latex also as prostheses, tissue grafts and systems of sustained release of bioactive compounds. For this purpose, physico-chemical and biological characterizations will be performed, which are commonly used in biomaterials and in dermal application.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BARROS, NATAN ROBERTO; AHADIAN, SAMAD; TEBON, PEYTON; CUNHA RUDGE, MARILZA VIEIRA; PASCON BARBOSA, ANGELICA MERCIA; HERCULANO, RONDINELLI DONIZETTI. Highly absorptive dressing composed of natural latex loaded with alginate for exudate control and healing of diabetic wounds. Materials Science & Engineering C-Materials for Biological Applications, v. 119, . (17/19603-8, 17/02518-8, 16/01743-5)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
BARROS, Natan Roberto de. Development of latex-alginate and latex-collagen polymer blends for application in tissue engineering. 2020. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Instituto de Química. Araraquara Araraquara.

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