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Dissolution analysis and in vitro biological characterization of SiO2-CaO-P2O5 system bioglasses doped with holmium

Grant number: 17/18753-6
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): December 01, 2017
Effective date (End): November 30, 2018
Field of knowledge:Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
Principal researcher:Juliana Marchi
Grantee:Giulia Piagentini Delpino
Home Institution: Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil


The search for new biomaterials for a better quality of life is recurrent, being very relevant nowadays the study of biomaterials with specific use to control and cure of malignant neoplasms through brachytherapy. Especially for bone cancer's treatment, the bioactive glass gains visibility as bioactive ceramics of high biocompatibility that favors the bond with the adjacent tissues. Aiming to merge the elimination of cancerous cells by radiation with the process of bone tissue's repair for a more effective treatment, bioactive glasses doped with radioactive source has been researched. From among those, Holmium is a promising alternative due to its superficial depth of radiation penetration and half-life time consistent with the treatment. Such material must be in adequate proportions, since high doping can compromise the performance of the bioactive glass in the ability to form a hydroxyapatite surface layer. As a specific objective, the proposed project aims to study the period of permanence and performance of this material, as well as its compatibility with the organism, through dissolution kinetics analyzes and biological characterization in vitro of SiO2-CaO-P2O5 system bioactive glasses doped with different concentrations of holmium, simulating physiological conditions. At the end of the project, it is expected to verify which concentrations of holmium incorporated in the bioactive glass have biological viability for use in biomedical applications. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DELPINO, GIULIA PIAGENTINI; BORGES, ROGER; ZAMBANINI, TELMA; SOUSA JOCA, JHONNY FRANK; GAUBEUR, IVANISE; SANTOS DE SOUZA, ANA CAROLINA; MARCHI, JULIANA. Sol-gel-derived 58S bioactive glass containing holmium aiming brachytherapy applications: A dissolution, bioactivity, and cytotoxicity study. Materials Science & Engineering C-Materials for Biological Applications, v. 119, . (16/23878-0, 17/18753-6)
ZAMBANINI, TELMA; BORGES, ROGER; FARIA, PAMELA C.; DELPINO, GIULIA P.; PEREIRA, ISIS S.; MARQUES, MARCIA M.; MARCHI, JULIANA. Dissolution, bioactivity behavior, and cytotoxicity of rare earth-containing bioactive glasses (RE = Gd, Yb). International Journal of Applied Ceramic Technology, v. 16, n. 5, SI, p. 2028-2039, . (17/18753-6, 16/16512-9, 11/19924-2)

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