Dissolution analysis and in vitro biological characterization of SiO2-CaO-P2O5 system bioglasses doped with holmium

Abstract

The search for new biomaterials for a better quality of life is recurrent, being very relevant nowadays the study of biomaterials with specific use to control and cure of malignant neoplasms through brachytherapy. Especially for bone cancer's treatment, the bioactive glass gains visibility as bioactive ceramics of high biocompatibility that favors the bond with the adjacent tissues. Aiming to merge the elimination of cancerous cells by radiation with the process of bone tissue's repair for a more effective treatment, bioactive glasses doped with radioactive source has been researched. From among those, Holmium is a promising alternative due to its superficial depth of radiation penetration and half-life time consistent with the treatment. Such material must be in adequate proportions, since high doping can compromise the performance of the bioactive glass in the ability to form a hydroxyapatite surface layer. As a specific objective, the proposed project aims to study the period of permanence and performance of this material, as well as its compatibility with the organism, through dissolution kinetics analyzes and biological characterization in vitro of SiO2-CaO-P2O5 system bioactive glasses doped with different concentrations of holmium, simulating physiological conditions. At the end of the project, it is expected to verify which concentrations of holmium incorporated in the bioactive glass have biological viability for use in biomedical applications. (AU)