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Effects of physical exercise training on brain structure and metabolism in patients undergoing bariatric surgery: randomized, controlled, clinical trial

Grant number: 17/16104-0
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): December 01, 2017
Effective date (End): January 31, 2021
Field of knowledge:Health Sciences - Physical Education
Principal Investigator:Bruno Gualano
Grantee:Carlos Alberto Abujabra Merege Filho
Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Saturated fatty acid excessive consumption increases the inflammatory response in the central nervous system. Obese patients undergoing magnetic resonance imaging showed decreased gray matter, distinct brain activation patterns and reduced cortical metabolism of appetite and cognitive areas. Bariatric surgery is considered an important strategy for the treatment of morbid obesity. Recent data demonstrates a partial improvement of brain metabolism after surgical intervention. Exercise training appears as an important tool to maintain the brain metabolism and structure of obese patients undergoing bariatric surgery. Until the present moment, there are no randomized, controlled clinical trials that attest to the benefits of exercise training on the brain metabolism and structure of these patients. This randomized, controlled and clinical trial aims to elucidate the effects of exercise training on brain metabolism and structure of obese patients undergoing bariatric surgery. In the baseline (PRE), after bariatric surgery (POS) and six months after exercise training (POS-6), patients will be submitted to magnetic resonance imaging technique in a 3Tesla machine to evaluate several brain parameters. In addition, the patients will be submitted to assessment of cognitive function, physical capacity, body composition and blood collection to evaluate the clinical parameters of insulin sensitivity and inflammatory markers.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE OLIVEIRA JUNIOR, GERSIEL NASCIMENTO; GOESSLER, KARLA FABIANA; PEREIRA SANTOS, JHONNATAN VASCONCELOS; DE LIMA, ALISSON PADILHA; GENARIO, RAFAEL; MEREGE-FILHO, CARLOS ALBERTO ABUJABRA; NUNES REZENDE, DIEGO AUGUSTO; DAMIOT, ANTHONY; DE CLEVA, ROBERTO; SANTO, MARCO AURELIO; et al. Home-Based Exercise Training During COVID-19 Pandemic in Post-Bariatric Patients: a Randomized Controlled Trial. OBESITY SURGERY, v. 31, n. 11, . (17/13552-2, 17/16104-0, 19/22160-6, 19/18039-7)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MEREGE FILHO, Carlos Alberto Abujabra. Effects of exercise training on functional connectivity and cerebral gray matter in patients undergoing bariatric surgery: a randomized controlled trial. 2023. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.

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