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Integrative genetic and regulatory network analysis to detect genes associated with muscle iron content and beef quality related phenotypes in Nelore

Grant number: 17/20761-7
Support Opportunities:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): March 01, 2018
Effective date (End): February 28, 2019
Field of knowledge:Agronomical Sciences - Animal Husbandry - Genetics and Improvement of Domestic Animals
Principal Investigator:Luciana Correia de Almeida Regitano
Grantee:Wellison Jarles da Silva Diniz
Supervisor: Haja Kadarmideen
Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
Research place: Technical University of Denmark (DTU), Denmark  
Associated to the scholarship:15/09158-1 - Identification of coexpression gene networks and regulatory mechanisms related to mineral composition and meat quality in bovine, BP.DR


Beef is a source of nutrients, mainly bioavailable iron. Iron (Fe) is essential to health because it plays an important role in many biological processes and imbalance in Fe homeostasis has been related to metabolic diseases. Despite genomic advances, knowledge about the genetic architecture underpinning the mineral content homeostasis in cattle muscle is still incipient. Muscle Fe content is a complex trait resulting from the coordinated interaction of many genes. Moreover, SNPs in regulatory elements and miRNAs may alter gene expression and contribute to phenotypic variation in the population. Given the background, systems genetic approaches based on genomic and transcriptomic data integration have been fruitful to identify regulatory genetic loci related to complex phenotypes. Therefore, this study aims to investigate the genetic mechanisms involved in the regulation of Fe content in the Nelore steers Longissimus dorsi muscle and its relationship with beef quality traits, integrating genomic (SNPs), transcriptomics (mRNAs and miRNAs) and phenotypic data. Gene co-expression and epistatic interaction networks will be constructed adopting WGCNA and WISH approaches. The results obtained will contribute to understanding the SNPs-miRNA-mRNA interaction, the muscle Fe homeostasis and its relationship with beef quality traits, as well as raise more information that could help to develop higher nutritional value beef. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DINIZ, WELLISON J. S.; MAZZONI, GIANLUCA; COUTINHO, LUIZ L.; BANERJEE, PRIYANKA; GEISTLINGER, LUDWIG; CESAR, ALINE S. M.; BERTOLINI, FRANCESCA; AFONSO, JULIANA; DE OLIVEIRA, PRISCILA S. N.; TIZIOTO, POLYANA C.; et al. Detection of Co-expressed Pathway Modules Associated With Mineral Concentration and Meat Quality in Nelore Cattle. FRONTIERS IN GENETICS, v. 10, . (12/23638-8, 15/09158-1, 17/20761-7)
DA SILVA DINIZ, WELLISON JARLES; BANERJEE, PRIYANKA; MAZZONI, GIANLUCA; COUTINHO, LUIZ LEHMANN; MELLO CESAR, ALINE SILVA; AFONSO, JULIANA; GROMBONI, CAIO FERNANDO; ARAUJO NOGUEIRA, ANA RITA; KADARMIDEEN, HAJA N.; DE ALMEIDA REGITANO, LUCIANA CORREIA. Interplay among miR-29 family, mineral metabolism, and gene regulation in Bos indicus muscle. Molecular Genetics and Genomics, v. 295, n. 5, p. 1113-1127, . (17/20761-7, 12/23638-8, 15/09158-1)

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