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Scaning of selection signatures in dairy buffalo (Bubalus bubalis)

Grant number: 17/10542-6
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): November 01, 2017
Effective date (End): July 29, 2020
Field of knowledge:Agronomical Sciences - Animal Husbandry - Genetics and Improvement of Domestic Animals
Principal Investigator:Humberto Tonhati
Grantee:André Vieira do Nascimento
Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil
Associated scholarship(s):18/25725-1 - Effects of inbreeding depression on milk production traits in Murrah buffaloes, BE.EP.DR


Changes in the morphology, physiology and behaviors of a species are reflexes of natural and/or artificial selection. These processes lead to specific genomics changes, so-called Selection Signatures (SS). The aim of the current study is search for SS in dairy buffaloes population raised in Brazil, in order to identify genomic regions potentially associated to economical traits underwent selection. A total of 652 samples of Murrah, genotyped to around 90,000 markers, contained in the panel Buffalo Axiom Genotyping, will be used. The genetic data will be submitted to quality control for markers and samples. The scanning of SS within population will be performed through of three different methodologies with different perspectives on selection signals: runs of homozygozity; the integrated haplotype score and the number of Segregating sites by Length (nSL). The genomic region highlighted as SS by any of approaches will be compared to results obtained with genome-wide association in buffaloes and explored for gene search, considering the UMD v3.1 assembly of the bovine genome. There is no knowledge about other studies using genomic tools to detect SS in buffaloes. Thus, it is justified the development of the current project with a purpose of generating information by different methodologies of SS identification, which is subsidized later studies. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
NASCIMENTO, V, A.; CARDOSO, D. F.; SANTOS, D. J. A.; ROMERO, A. R. S.; SCALEZ, D. C. B.; BORQUIS, R. R. A.; NETO, F. R. A.; GONDRO, C.; TONHATI, H.. Inbreeding coefficients and runs of homozygosity islands in Brazilian water buffalo. JOURNAL OF DAIRY SCIENCE, v. 104, n. 2, p. 1917-1927, . (17/10542-6, 16/21213-0, 16/22490-8)
NASCIMENTO, A. V.; ROMERO, A. R. S.; NAWAZ, M. Y.; CARDOSO, D. F.; SANTOS, D. J. A.; GONDRO, C.; TONHATI, H.. An updated Axiom buffalo genotyping array map and mapping of cattle quantitative trait loci to the new water buffalo reference genome assembly. ANIMAL GENETICS, v. 52, n. 4, p. 505-508, . (18/25725-1, 17/10542-6, 16/21213-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
NASCIMENTO, André Vieira do. Scaning of Selection Signatures in Dairy Buffalo (Bubalus bubalis). 2020. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Ciências Agrárias e Veterinárias. Jaboticabal Jaboticabal.

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