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Integrative approach on the sustainable prospection of marine natural products: from diversity to anticancer compounds

Grant number: 17/17648-4
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): October 01, 2017
Effective date (End): January 05, 2023
Field of knowledge:Biological Sciences - Pharmacology - Biochemical and Molecular Pharmacology
Principal researcher:Leticia Veras Costa Lotufo
Grantee:Anelize Bauermeister
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:15/17177-6 - Integrative approach on the sustainable prospection of marine natural products: from diversity to anticancer compounds, AP.BTA.TEM
Associated scholarship(s):18/24865-4 - New approaches in metabolomics: 3D Molecular cartography of ascidians based on LC-MS/MS data, BE.EP.PD


Brazilian marine ecosystems have great strategic importance for the country. Nonetheless, the sustainable use of marine natural resources is still a challenging endeavor. In fact, in many cases we even ignore what are the resources available, in view of the lack of information concerning biodiversity and ecosystems functioning. Thus, this project was conceived for the development of an integrative research strategy, in order to establish a new paradigm for bioprospection.I. Intellectual Merit: This proposal aims at providing an integrative approach to understand how diversity at different organization levels interact and may drive the production of secondary metabolites with interesting pharmacological properties, especially those related to cancer therapy. In particular, the leading premise is combining different approaches, including culture dependent (bioactivity and target-guided) and independent (metabolomics and metagenomics) studies, and also bring to context the underlying processes driving the biodiversity organization and functioning. The elected targets, the anti-senescence transcription factors Tbx2 and Tbx3, are involved in the tumorigenic process, but with no exogenous modulator described so far. The potential identification of new natural molecules from the Brazilian biodiversity targeting Tbx2 and Tbx3 bring to this project a strong innovative potential.II. Broader Impacts: Within the paradigm of sustainable use of natural resources, a core value in all diversity conservation programs, the integrative approach herein presented should be used for a comprehensive evaluation of emerging patterns driving diversity in different levels: from genes to secondary metabolites. III. Integration: The proposed integrative approach proposed brings together scientists from different research areas working under a common set of objectives, sharing data through electronic tools and brewing together ideas to promote knowledge on biodiversity conservation and sustainable use. It is worth mentioning, especially, that this project is essentially multidisciplinary and with great potential for innovation, as it is inserted in an extremely promising area, motivated by a sustainable exploration of marine resources in order to identify new biotechnological products, as well as to legitimize new anticancer molecular targets.

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Scientific publications (10)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FURTADO, LUCIANA C.; BAUERMEISTER, ANELIZE; DE FELICIO, RAFAEL; ORTEGA, RAQUEL; PINTO, FRANCISCO DAS CHAGAS L.; MACHADO-NETO, JOAO AGOSTINHO; TRIVELLA, DANIELA B. B.; PESSOA, OTILIA D. L.; WILKE, DIEGO V.; LOPES, NORBERTO P.; et al. Marine Streptomyces sp. Isolated From the Brazilian Endemic Tunicate Euherdmania sp. Produces Dihydroeponemycin and Analogs With Potent Antiglioma Activity. FRONTIERS IN MARINE SCIENCE, v. 8, . (18/24865-4, 17/18235-5, 15/17177-6, 17/17648-4)
WILKE, V, DIEGO; JIMENEZ, PAULA C.; BRANCO, PAOLA C.; REZENDE-TEIXEIRA, PAULA; TRINDADE-SILVA, AMARO E.; BAUERMEISTER, ANELIZE; LOPES, NORBERTO PEPORINE; COSTA-LOTUFO, V, LETICIA. Anticancer Potential of Compounds from the Brazilian Blue Amazon. Planta Medica, v. 87, n. 01/02, . (15/17177-6, 14/50926-0, 17/09022-8, 17/17648-4)
REZENDE-TEIXEIRA, PAULA; DUSI, RENATA G.; JIMENEZ, PAULA C.; ESPINDOLA, LAILA S.; COSTA-LOTUFO, V, LETICIA. hat can we learn from commercial insecticides? Efficacy, toxicity, environmental impacts, and future development. Environmental Pollution, v. 300, . (17/09022-8, 14/50926-0, 15/17177-6, 17/17648-4)
BAUERMEISTER, ANELIZE; CALIL, FELIPE A.; PINTO, FRANCISCO DAS C. L.; MEDEIROS, TALITA C. T.; ALMEIDA, LARISSA C.; SILVA, LEONARDO J.; DE MELO, ITAMAR S.; ZUCCHI, TIAGO D.; COSTA-LOTUFO, LETICIA V.; MORAES, LUIZ A. B.. Pradimicin-IRD from Amycolatopsis sp. IRD-009 and its antimicrobial and cytotoxic activities. NATURAL PRODUCT RESEARCH, v. 33, n. 12, p. 1713-1720, . (17/17648-4, 13/50729-7)
CONDE-MARTINEZ, NATALIA; BAUERMEISTER, ANELIZE; PILON, ALAN CESAR; LOPES, NORBERTO PEPORINE; TELLO, EDISSON. Integrating Molecular Network and Culture Media Variation to Explore the Production of Bioactive Metabolites by Vibrio diabolicus A1SM3. MARINE DRUGS, v. 17, n. 4, . (16/13292-8, 17/17648-4)
PINTO, FRANCISCO C. L.; SILVEIRA, EDILBERTO R.; VASCONCELOS, ANA CAROLINE L.; FLORENCIO, KATHARINE G. D.; OLIVEIRA, FRANCISCA A. S.; SAHM, BIANCA B.; COSTA-LOTUFO, V, LETICIA; BAUERMEISTER, ANELIZE; LOPES, NORBERTO P.; WILKE, V, DIEGO; et al. Dextrorotatory Chromomycins from the Marine Streptomyces sp. Associated to Palythoa caribaeorum. Journal of the Brazilian Chemical Society, v. 31, n. 1, p. 143-152, . (14/50926-0, 17/17648-4, 15/17177-6)
DE ALMEIDA, LARISSA COSTA; BAUERMEISTER, ANELIZE; REZENDE-TEIXEIRA, PAULA; DOS SANTOS, EVELYNE ALVES; BERALDO DE MORAES, LUIZ ALBERTO; MACHADO-NETO, JOAO AGOSTINHO; COSTA-LOTUFO, LETICIA VERAS. Pradimicin-IRD exhibits antineoplastic effects by inducing DNA damage in colon cancer cells. Biochemical Pharmacology, v. 168, p. 38-47, . (18/17595-0, 15/17177-6, 17/17648-4, 14/50926-0, 17/24993-0)
TANGERINA, MARCELO M. P.; FURTADO, LUCIANA COSTA; LEITE, VIDA M. B.; BAUERMEISTER, ANELIZE; VELASCO-ALZATE, KAREN; JIMENEZ, PAULA C.; GARRIDO, LEANDRO M.; PADILLA, GABRIEL; LOPES, NORBERTO P.; COSTA-LOTUFO, LETICIA V.; et al. Metabolomic study of marine Streptomyces sp.: Secondary metabolites and the production of potential anticancer compounds. PLoS One, v. 15, n. 12, . (17/16606-6, 15/17177-6, 17/18235-5, 17/17648-4)
JIMENEZ, PAULA C.; WILKE, DIEGO V.; BRANCO, PAOLA C.; BAUERMEISTER, ANELIZE; REZENDE-TEIXEIRA, PAULA; GAUDENCIO, SUSANA P.; COSTA-LOTUFO, LETICIA V.. Enriching cancer pharmacology with drugs of marine origin. British Journal of Pharmacology, v. 177, n. 1, p. 3-27, . (17/09022-8, 17/17648-4, 15/17177-6)

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