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Characterization of Plasmids Associated with the Spread of the Colistin Resistance mcr-1 gene in Clinically Significant Enterobacteriaceae from South American and European Countries

Grant number: 17/16754-5
Support Opportunities:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): January 10, 2018
Effective date (End): April 24, 2018
Field of knowledge:Biological Sciences - Microbiology - Applied Microbiology
Principal Investigator:Nilton Erbet Lincopan Huenuman
Grantee:Miriam Rodriguez Fernandes
Supervisor: Alessandra Carattoli
Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Research place: Istituto Superiore di Sanità (ISS), Italy  
Associated to the scholarship:15/13527-2 - Ancestral relationship, pan-resistoma plasmid of Escherichia coli producing b-lactamases of extended spectrum (CTX-M) and of plasmid curing methods, BP.DR


The emergence and rapid dissemination of the plasmid-mediated mcr-1 gene among colistin-resistant Enterobacteriaceae has created an urgent need to elucidate the mechanisms involved in mcr-1 gene transfer. The increased incidences of the mcr-1 gene and its reports at global scale have revealed the hazard of the plasmid-mediated colistin-resistant in 44 countries, so far. Furthermore, plasmid carrying mcr-1 gene has been identified from different sources, including humans, livestock, companion animals, wild-animals, food, and aquatic environments, which reinforces the ubiquity of these plasmids. To our knowledge, mcr-1-harbouring plasmids have been grouped into eight replicon types: IncI2, IncX4, IncHI1, IncHI2, IncF, IncFI, IncFII, and IncP. Interestingly, IncX4-type plasmids carrying the mcr-1 gene have disseminated in a pandemic scale, being reported in 15 countries. In Brazil, IncX4 plasmids carrying mcr-1 have been identified among ESBL (CTX-M)- and KPC-2-producing Escherichia coli and Klebsiella pneumoniae from healthy livestock, infected human, sea birds, chicken meat and marine environment, in ten different states; whereas the presence of others worldwide disseminated plasmids has not been reported in Brazil. The present study aims to characterize and compare plasmids carrying mcr-1 gene occurring in Enterobacteriaceae recovered from clinical and non-clinical samples in South American and European countries.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ESPINAL, P.; NUCLEO, E.; CALTAGIRONE, M.; MARCHETTI, V. MATTIONI; FERNANDES, M. R.; BISCARO, V; RIGOLI, R.; CARATTOLI, A.; MIGLIAVACCA, R.; VILLA, L.. Genomics of Klebsiella pneumoniae ST16 producing NDM-1, CTX-M-15, and OXA-232. Clinical Microbiology and Infection, v. 25, n. 3, . (17/16754-5)

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