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Analyse of the B2 receptor of kinins polymorphism in obese adolescents submitted a one year of interdisciplinary therapy

Grant number: 17/16198-5
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): October 01, 2017
Effective date (End): September 30, 2018
Field of knowledge:Biological Sciences - Genetics - Human and Medical Genetics
Principal researcher:Ronaldo de Carvalho Araújo
Grantee:Thaís Emanuele de Almeida
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Because to the large increase in the number of overweight and obese people in Brazil and in the world, this populations became targets of studies. Among the numerous diseases that affect the population, one of the most common is hypertension, characterized by the high pressure exerted by the blood inside the blood vessels. There is a great deal of evidence that the practice of regular physical activity assists in the treatment and rehabilitation of various diseases, including hypertension, besides that, many genetic polymorphisms are linked to diseases and cellular responses, as well as to physical performance. There are several genes and genetic variables that can be identified as variables of individuals associated with a genetic predisposition for hypertension, among them BDKRB2 that encodes the bradykinin B2 receptor that has been studied for it's vasodilator potential and for a protective role against hypertension. A common genetic variation of this gene (localization: 14q32) is characterized by the deletion of 9 base pairs, related to an increase in gene expression, and the expression levels of this gene are related to several pathologies such as atherosclerosis, hypertension, diabetes, and pre-eclampsia; in addition, the -9 allele has been associated with greater metabolic efficiency of skeletal muscle and in physical performance during resistance training. Thus, genetic variability in the BDKRB2 gene may potentially modulate vascular response to physical training, in which the +9 allele has been associated with decreased gene transcription and mRNA expression and reduced cardiac trophic response to training. Thus, the objective of this work is understand how genetic factors can interact with lifestyle (physically active) in relation to the incidence of hypertension in obese adolescents. (AU)

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