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Effect of vagal stimulation during LPS immune challenge in normotensive and spontaneously hypertensive rats

Grant number: 17/09878-0
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): September 01, 2017
Effective date (End): November 30, 2021
Field of knowledge:Biological Sciences - Physiology - General Physiology
Principal researcher:Luiz Guilherme de Siqueira Branco
Grantee:Mateus Ramos Amorim
Home Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:16/17681-9 - Pathophysiological changes during systemic inflammation, AP.TEM
Associated scholarship(s):19/13249-3 - The role of leptin signaling in the dorsomedial hypothalamus in the upper airway patency during sleep, BE.EP.PD

Abstract

The systemic inflammatory response syndrome (SIRS) is an inflammatory condition which affects the whole body and represents a serious threat. Endotoxemia, sepsis and its complications (septic shock and multiple organ failure) are the major cause of death in intensive care units worldwide, despite recent major technological advances. In spite of endotoxemia, hypertension is also a disease which may lead to a significant medical and social impact, being characterized by elevated and sustained blood pressure levels and associated with changes in the reflex mechanisms that regulate the cardiovascular system. There is an experimental similarity between the pathophysiology of essential hypertension in men with spontaneously hypertensive rats (SHR). These animals, as well as hypertensive humans, have a marked sympathetic overactivity and decreased vagal cardiac tone. Clinical studies have shown that in situations where there is less parasympathetic activity, the inflammatory processes seems to be more pronounced. The aim of this study is to test the hypothesis that, in the face of the immune challenge caused by LPS, SHR will be particularly more sensitive to vagal stimulation (induced by pyridostigmine treatment), since these animals have reduced vagal tonus compared to normotensive rats. To better study this mechanism, we will quantify the plasma concentration of PGE2 and PGD2 and also cytokines (IL-1, IL-6 and TNF-± and IL-10) in these animals. We suggest that there is an inversely proportional relationship between vagal tone and PGE2 and a directly proportional parallel between vagal tone and PGD2, considering that they are pro and antipyretic mediators, respectively.

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Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
AMORIM, MATEUS R.; DE DEUS, JUNIA L.; PEREIRA, CAMILA A.; DA SILVA, LUIZ E. V.; BORGES, GABRIELA S.; FERREIRA, NATHANNE S.; BATALHAO, MARCELO E.; ANTUNES-RODRIGUES, JOSE; CARNIO, EVELIN C.; TOSTES, RITA C.; et al. Baroreceptor denervation reduces inflammatory status but worsens cardiovascular collapse during systemic inflammation. SCIENTIFIC REPORTS, v. 10, n. 1, . (16/17681-9, 17/09878-0)
NOGUEIRA, JONATAS E.; AMORIM, MATEUS R.; PINTO, ANA P.; DA ROCHA, ALISSON L.; DA SILVA, ADELINO S. R.; BRANCO, LUIZ G. S.. Molecular hydrogen downregulates acute exhaustive exercise-induced skeletal muscle damage. Canadian Journal of Physiology and Pharmacology, v. 99, n. 8, p. 812-820, . (17/09878-0, 16/17681-9, 17/19869-8, 17/12765-2)
AMORIM, MATEUS R.; DE JESUS, ALINE A.; SANTOS-JUNIOR, NILTON N.; ROCHA, MARIA J. A.; NOGUEIRA, JONATAS E.; BATALHAO, MARCELO E.; CARNIO, EVELIN C.; BRANCO, LUIZ G. S.. Autonomic Disbalance During Systemic Inflammation is Associated with Oxidative Stress Changes in Sepsis Survivor Rats. Inflammation, . (17/09878-0, 16/17681-9)
AMORIM, MATEUS R.; MOREIRA, DIEGO A.; SANTOS, BRUNA M.; FERRARI, GUSTAVO D.; NOGUEIRA, JONATAS E.; DE DEUS, JUNIA L.; ALBERICI, LUCIANE C.; BRANCO, LUIZ G. S.. Increased lipopolysaccharide-induced hypothermia in neurogenic hypertension is caused by reduced hypothalamic PGE(2)production and increased heat loss. JOURNAL OF PHYSIOLOGY-LONDON, . (17/09878-0, 16/17681-9)
AMORIM, MATEUS R.; DE DEUS, JUNIA L.; CAZUZA, RAFAEL A.; MOTA, CLARISSA M. D.; DA SILVA, LUIZ E. V.; BORGES, GABRIELA S.; BATALHAO, MARCELO E.; CARNIO, EVELIN C.; BRANCO, LUIZ G. S.. Neuroinflammation in the NTS is associated with changes in cardiovascular reflexes during systemic inflammation. JOURNAL OF NEUROINFLAMMATION, v. 16, . (16/17681-9, 17/01633-8, 17/09878-0)
MOTA, CLARISSA M. D.; BORGES, GABRIELA S.; AMORIM, MATEUS R.; CAROLINO, RUITHER O. G.; BATALHAO, MARCELO E.; ANSELMO-FRANCI, JANETE A.; CARNIO, EVELIN C.; BRANCO, LUIZ G. S.. Central serotonin prevents hypotension and hypothermia and reduces plasma and spleen cytokine levels during systemic inflammation. BRAIN BEHAVIOR AND IMMUNITY, v. 80, p. 255-265, . (17/09878-0, 16/17681-9)
DE DEUS, JUNIA LARA; AMORIM, MATEUS RAMOS; GAMA DE BARCELLOS FILHO, PROCOPIO CLEBER; CORTES DE OLIVEIRA, JOSE ANTONIO; BATALHAO, MARCELO EDUARDO; GARCIA-CAIRASCO, NORBERTO; CARNIO, EVELIN CAPELLARI; LEAO, RICARDO MAURICIO; DE SIQUEIRA BRANCO, LUIZ GUILHERME; SIQUEIRA CUNHA, ALEXANDRA OLIMPIO. Inflammatory markers in the hippocampus after audiogenic kindling. Neuroscience Letters, v. 721, . (17/09878-0, 15/22327-7, 16/01607-4, 16/17681-9)

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