Sensitivity to 3-bromopyruvate and its relation to monocarboxylate 1 transporter ...
Characterization of the expression of monocarboxylate transporters in small cell l...
Grant number: | 17/09226-2 |
Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
Start date until: | July 01, 2017 |
End date until: | June 30, 2019 |
Field of knowledge: | Biological Sciences - Biochemistry - Metabolism and Bioenergetics |
Principal Investigator: | Céline Marques Pinheiro |
Grantee: | Lara Esquiapatti Pinheiro |
Host Institution: | Hospital do Câncer de Barretos. Fundação Pio XII (FP). Barretos , SP, Brazil |
Abstract Unknown primary site tumors (CUPs) are characterized by the occurrence of metastases associated with the absence of recognition of the original place. CUP is a heterogeneous group that have a little response to conventional cytotoxic chemotherapy, in general. It has an overall survival about 3-6 months after diagnosis. The metabolic alterations of the cancer cells allow the proliferation and cellular growth in a singular way, independently of O2 supply or absence (Warburg Effect). Therefore, characterization of the metabolic profile of CUPs may stimulate the search for evidences of the role of proteins involved in metabolism reprogramming as tumor markers, as well as potential therapeutic targets. Objective: This scientific project aims to characterize MCT1 and MCT2 expression in unknown primary site tumor and, also, associate the results with the clinical-pathological data of patients diagnosed with CUP. Materials and Methods: MCT1 and MCT2 expression will be analyzed by immunohistochemistry, in a series of about 120 CUPs. The final graduation will be composed by the extension and intensity parameters sum. Finally, the findings will be associated with the clinical and pathological data of the patients diagnosed with CUP, using SPSS. (AU) | |
News published in Agência FAPESP Newsletter about the scholarship: | |
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