Scholarship 17/09226-2 - Neoplasias primárias desconhecidas, Transportadores de ácidos monocarb - BV FAPESP
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Characterization of MCT1 and MCT2 expression in tumors of unknown primary site

Grant number: 17/09226-2
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Start date until: July 01, 2017
End date until: June 30, 2019
Field of knowledge:Biological Sciences - Biochemistry - Metabolism and Bioenergetics
Principal Investigator:Céline Marques Pinheiro
Grantee:Lara Esquiapatti Pinheiro
Host Institution: Hospital do Câncer de Barretos. Fundação Pio XII (FP). Barretos , SP, Brazil

Abstract

Unknown primary site tumors (CUPs) are characterized by the occurrence of metastases associated with the absence of recognition of the original place. CUP is a heterogeneous group that have a little response to conventional cytotoxic chemotherapy, in general. It has an overall survival about 3-6 months after diagnosis. The metabolic alterations of the cancer cells allow the proliferation and cellular growth in a singular way, independently of O2 supply or absence (Warburg Effect). Therefore, characterization of the metabolic profile of CUPs may stimulate the search for evidences of the role of proteins involved in metabolism reprogramming as tumor markers, as well as potential therapeutic targets. Objective: This scientific project aims to characterize MCT1 and MCT2 expression in unknown primary site tumor and, also, associate the results with the clinical-pathological data of patients diagnosed with CUP. Materials and Methods: MCT1 and MCT2 expression will be analyzed by immunohistochemistry, in a series of about 120 CUPs. The final graduation will be composed by the extension and intensity parameters sum. Finally, the findings will be associated with the clinical and pathological data of the patients diagnosed with CUP, using SPSS. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BONATELLI, MURILO; FORNARI, ISABELLA FERNANDES; BERNECULE, PRISCILA NEVES; PINHEIRO, LARA ESQUIAPATTI; COSTA, RICARDO FILIPE ALVES; LONGATTO-FILHO, ADHEMAR; JUNIOR, JOAO NEIF ANTONIO; SILVA, EDUARDO CAETANO ALBINO; CARCANO, FLAVIO MAVIGNIER; PINHEIRO, CELINE. Expression of Glycolysis-Related Proteins in Cancer of Unknown Primary Origin. FRONTIERS IN ONCOLOGY, v. 11, . (17/09226-2, 16/08674-9)

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