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Effect of lipid-lowering drugs on endothelial function and vascular stiffness in patients with dermatomyositis and polymyositis: a prospective, double-blind, randomized controlled trial

Grant number: 16/20371-1
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): September 01, 2017
Effective date (End): August 31, 2019
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Samuel Katsuyuki Shinjo
Grantee:Isabela Bruna Pires Borges
Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Dermatomyositis (DM) and polymyositis (PM) are idiopathic inflammatory myopathies characterized by the presence of progressive proximal muscle weakness of limbs. Metabolic syndrome (MS) is a series of biochemical and physiological disorders characterized by fasting plasma glucose change, central obesity, dyslipidemia and hypertension. The clinical relevance of MS is related to its role in the development of cardiovascular diseases and diabetes mellitus. The presence of MS is also directly related to endothelial dysfunction of the vascular and arterial stiffness, which lead to increased cardiovascular morbidity and mortality.There are few studies that describe the prevalence of MS in systemic autoimmune rheumatic diseases varying from 14 to 62.8% and, therefore, higher than in the general population. This high prevalence suggests that the presence of these systemic autoimmune diseases or instituted treatment influence the risk of developing MS. Our research group has pioneered demonstrated a high prevalence of MS in patients with DM/PM, characterized by elevated serum levels of total cholesterol, LDL-cholesterol and triglycerides, and low serum HDL-cholesterol.The high MS prevalence, particularly dyslipidemia, in DM/PM, along with the chronic use of corticosteroids, presence of functional disability, sedentary lifestyle or even bed rest for some patients, increase cardiovascular risk and mortality in this population. The identification of risk factors for cardiovascular disease in patients with DM/PM is important in clinical practice so that we can carry out early intervention mainly on modifiable risk factors and, therefore, minimizing cardiovascular risks.This study is a clinical double-blind randomized trial. It is part of a series of clinical trials that aim increase the knowledge of lipid-lowering drug effect on endothelial function and vascular stiffness in patients with DM and PM. Until now, the real impact on the lipid-lowering therapy in patients with diagnosis of DM/PM. Although not scientifically proven, it is believed that these drugs may eventually relapse or worse disease activity. For this reason their use in medical practice in this population has been avoided. Moreover, the impact of the use of lipid-lowering drugs on endothelial function and arterial stiffness in patients with DM/PM is also unknown, which motivated us to conduct this study. (AU)

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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE OLIVEIRA, DIEGO SALES; PIRES BORGES, ISABELA BRUNA; DE SOUZA, JEAN MARCOS; GUALANO, BRUNO; RODRIGUES PEREIRA, ROSA MARIA; SHINJO, SAMUEL KATSUYUKI. Exercise training attenuates insulin resistance and improves beta-cell function in patients with systemic autoimmune myopathies: a pilot study. CLINICAL RHEUMATOLOGY, v. 38, n. 12, p. 3435-3442, . (16/19771-5, 16/20371-1, 17/13109-1)
PIRES BORGES, ISABELA BRUNA; SHINJO, SAMUEL KATSUYUKI. Safety of statin drugs in patients with dyslipidemia and stable systemic autoimmune myopathies. RHEUMATOLOGY INTERNATIONAL, v. 39, n. 2, p. 311-316, . (15/12628-0, 16/20371-1)
DOS SANTOS, ALEXANDRE MOURA; MISSE, RAFAEL GIOVANI; PIRES BORGES, ISABELA BRUNA; SHINJO, SAMUEL KATSUYUKI. The aerobic capacity in patients with antisynthetase syndrome and dermatomyositis. ADVANCES IN RHEUMATOLOGY, v. 60, n. 1, . (17/13109-1, 16/23574-0, 18/08735-3, 16/20371-1)
PIRES BORGES, ISABELA BRUNA; DE OLIVEIRA, DIEGO SALES; MISSE, RAFAEL GIOVANI; DOS SANTOS, ALEXANDRE MOURA; COSTA HONG, VALERIA APARECIDA; BORTOLOTTO, LUIZ APARECIDO; SHINJO, SAMUEL KATSUYUKI. Safety of Atorvastatin in Patients With Stable Systemic Autoimmune Myopathies A Pilot Longitudinal Study. JCR-JOURNAL OF CLINICAL RHEUMATOLOGY, v. 27, n. 6, p. S236-S241, . (16/19771-5, 16/23574-0, 18/08735-3, 17/13109-1, 16/20371-1)
MISSE, RAFAEL GIOVANI; PIRES BORGES, ISABELA BRUNA; SHINJO, SAMUEL KATSUYUKI. Endothelial function features and properties of large vessel behavior in systemic autoimmune diseases: a cross-talk among cardiovascular disease risk factors. AUTOIMMUNITY REVIEWS, v. 18, n. 6, p. 637-638, . (17/13109-1, 16/23574-0, 16/20371-1)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
BORGES, Isabela Bruna Pires. Is atorvastatin safe to patients with systemic autoimmune myopathies?: a prospective, randomized, double-blind, placebo-controlled study. 2019. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.

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