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long-therm clinical evaluation of in-office dental bleaching using a violet light (led 405-410 nm)

Grant number: 16/24126-1
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): August 01, 2017
Effective date (End): February 29, 2020
Field of knowledge:Health Sciences - Dentistry - Dental Clinics
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Patricia Moreira de Freitas Costa e Silva
Grantee:Eric Mayer dos Santos
Host Institution: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):18/03983-9 - Effect of Violet LED (405-410nm) application on dentin structure, BE.EP.DR


The objective of this clinical study is to evaluate the effect of the whitening treatment performed with the violet LED light (405-410 nm), with or without a bleaching gel, on the tooth color changes (immediate and long-term), tooth sensitivity, satisfaction of participants in relation to the technique, impact on their quality of life, alteration in the enamel surface morphology and increase in pulp temperature. Before the clinical phase (Phase 2), an in vitro thermographic evaluation of the proposed treatments (Phase 1) will be performed using 30 samples obtained from third molars, which will be divided into 3 groups (n = 10): G1 - 35% Hydrogen Peroxide (HP) (4 sessions, 1 session / week); G2 - violet LED (405-410 nm, 4 sessions, 1 session / week); G3 - hybrid technique (violet LED + 35% HP + violet LED) (4 sessions, 1 session / week). In phase 2, 100 participants will be selected and randomly divided into a treatment group (n = 25): G1 - 35% hydrogen peroxide (4 sessions, 1 session/week); G2 - Violet LED (405-410 nm, 4 sessions, 1 session/week); G3 - Violet LED (405-410 nm, 4 sessions, 2 sessions/week); G4 - hybrid technique HP (Violet LED + 35% HP + violet LED) (4 sessions, 1 session/week). The color evaluation will be performed at predetermined times (before and immediately after treatment, 14 days after completion of bleaching and 3, 6 and 12 months after completion of bleaching), and quantitatively evaluated by colorimetric tests (objective and subjective) and spectrophotometry. In addition, it will be evaluated the tooth sensitivity during and after (48 hours) tooth whitening (VAS Scale), satisfaction with the treatment and impact on quality of life (OHIP-14 questionnaire). A qualitative analysis of the morphological alterations in enamel will be performed with scanning electron microscopy on epoxy resin replicas obtained from the impression of dental enamel of 5 volunteers (randomly chosen) of each of the 4 groups of Phase 2. The data, except for survey data of satisfaction and surface morphology (descriptive evaluation), will be subjected to statistical analysis to determine the homogeneity and normality of the sample and for comparison between treatment groups, considering a 5% significance level. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MAYER-SANTOS, ERIC; MARAVIC, TATJANA; COMBA, ALLEGRA; FREITAS, PATRICIA MOREIRA; MARINHO, GIOVANNA BUENO; MAZZITELLI, CLAUDIA; MANCUSO, EDOARDO; SCOTTI, NICOLA; FLORENZANO, FEDERICA; BRESCHI, LORENZO; et al. The Influence of Different Bleaching Protocols on Dentinal Enzymatic Activity: An In Vitro Study. Molecules, v. 27, n. 5, p. 11-pg., . (16/24126-1, 18/03983-9)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SANTOS, Eric Mayer dos. Clinical evaluation of in-office bleaching using a Violet LED (405-410 nm). 2020. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Odontologia (FO/SDO) São Paulo.

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