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Strength training as an anabolic agent in senile rats: analysis of osteoblastic and osteoclast markers after tibial osteotomy

Grant number: 17/06578-5
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2017
Effective date (End): December 31, 2017
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Rita Cássia Menegati Dornelles
Grantee:Viviane Bento de Barros
Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil


Estrogen exerts an important role in bone remodeling, maintaining the balance between formation and resorption, stimulating the expression of OPG and inhibiting the activation of RANKL. Therefore, estrogen deficiency as detected in women during aging favors the incidence of osteoporosis and the risk of fracture, since this deficiency leads to an imbalance between reabsorption and bone formation, where increased bone resorption exceeds that of formation. As prevention, it is already agreed in the literature that physical activity promotes improvement in bone quality and bone mass in peri and postmenopausal women. However, there is a need to elucidate whether the strength training can influence the RANK / RANKL / OPG system in the bone metabolism of senile rats and what impact on the bone repair process after fracture. Objective: To evaluate the RANK / RANKL / OPG system after total tibial osteotomy in senile rats submitted to strength training. Methodology: For the present study, 40 Wistar rats with initial age of 17 months will be used. After 15 days of analysis of the estrous cycle, the animals (18 months) will be distributed in the following experimental groups: NT (no trained) and ST (strength training), consisting of 20 animals each. After the experimental period, performed for 120 days, unilateral total osteotomy will be performed in the left tibia in all animals that will be euthanized at two experimental times, 1 week and 8 weeks after the osteotomy, to evaluate the response to the initial and final fracture, respectively. (AU)

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