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Canine adipose-derived mesenchymal stem cells viability following exposure to different molecular weights of hyaluronic acid

Grant number: 17/04510-4
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2017
Effective date (End): December 31, 2017
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
Principal Investigator:Maria Angelica Miglino
Grantee:Beatriz Do Valle Todesco
Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil


The transplantation of mesenchymal stem cells (MSC) is becoming a promising treatment for osteoarthritis (OA), as well the intra-articular application of hyaluronic acid (HA), that has been shown effective in pain reduction and supporting the homeostasis in the articular environment. Moreover, the combination of HA with MSC has been demonstrated as a therapeutic potential for OA treatment. However, considering the different molecular weights of HA available for therapy, it is important to study the effects of these different molecular weights in contact with MSC. It will be evaluated canine adipose derived mesenchymal stem cells viability following exposure to high and low molecular weights of hyaluronic acid. Cells were harvested and assessed for viability using trypan blue exclusion. (AU)

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