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Protein Interaction in TiO2 Thin Films Surfaces

Grant number: 16/22186-7
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): June 01, 2017
Effective date (End): March 31, 2019
Field of knowledge:Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Paulo Noronha Lisboa Filho
Grantee:Orisson Ponce Gomes
Host Institution: Faculdade de Ciências (FC). Universidade Estadual Paulista (UNESP). Campus de Bauru. Bauru , SP, Brazil
Associated research grant:13/07296-2 - CDMF - Center for the Development of Functional Materials, AP.CEPID


This proposal is associated to the Health Division for The Center for Development of Functional Materials (CDFM / CEPID / FAPESP 2013 / 07296-2) and has the general objective to develop a new generation of bio-multifunctional titanium dioxide surfaces for dental implants in order to obtain biologically selective surfaces while promoting proper adhesion of osteoblastic cells while minimizing the potential colonization by undesired microorganisms together with high corrosion resistance and tribocorrosion.The tailoring of surface involves a large number of experimental procedures level of modification of surfaces and interfaces to study the interactions between the bulk and surface modifier. These may promote improved resistance biocorrosion the material and increase the bioactivity of oxides, with promising results in the interaction with the tissue, since the biocompatibility is determined by chemical processes occurring in the interface between the prosthesis and the living tissue. The biological performance of these materials and other properties such as resistance to biocorrosion, chemical resistance, and bioactivity can be improved by modifying their surfaces, wherein the metallic oxides have shown good results in the interaction with proteins, which is the initial process for an interaction the biological environment to the material. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GOMES, O. P.; FELTRAN, G. S.; FERREIRA, M. R.; ALBANO, C. S.; ZAMBUZZI, W. F.; LISBOA-FILHO, P. N.. A novel BSA immobilizing manner on modified titanium surface ameliorates osteoblast performance. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 190, . (16/22186-7, 14/22689-3, 17/15035-5, 13/07296-2, 14/20471-0)
GOMES, ORISSON P.; AZEVEDO NETO, NILTON F.; BRONZE-UHLE, ERIKA S.; TRINO, LUCIANA D.; DOS SANTOS, CASSIO M.; DA SILVA, JOSE H. D.; LISBOA-FILHO, PAULO N.. 3-Mercaptopropionic acid functionalization of titanium dioxide thin films. Materials Chemistry and Physics, v. 223, p. 32-38, . (16/22186-7, 13/07296-2, 14/20471-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
GOMES, Orisson Ponce. Protein interaction on TiO2 thin films surfaces and their biological response. 2019. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Ciências. Bauru Bauru.

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