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Photoacoustic waves and ionizing radiation: laser and X-ray photoacoustic imaging

Grant number: 16/22720-3
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): September 08, 2017
Effective date (End): August 17, 2018
Field of knowledge:Engineering - Biomedical Engineering - Bioengineering
Principal researcher:Theo Zeferino Pavan
Grantee:Diego Ronaldo Thomaz Sampaio
Supervisor abroad: Richard Robert Bouchard
Home Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Research place: University of Texas MD Anderson Cancer Center (MD Anderson), United States  
Associated to the scholarship:15/05684-0 - Laser and X-ray induced photoacoustic imaging, BP.DR


Photoacoustics is an area of great and still increasing interest. Photoacoustic imaging is now attracting more investigation since it can provide physio-chemical information of tissue non-invasively. In imaging physics, x-ray acoustic imaging is presented as a new tool that have been discussed for radiation detection during external beam radiation therapy (EBRT), providing opportunities to be applied in dosimetry. It is known that multi-wavelength photoacoustic imaging adds molecular information to photoacoustic imaging, obtaining concentrations of endogenous chromophores such as hemoglobin, but more specifically whether it is bound to oxygen or not. In this context, photoacoustic-based images can potentially be employed during cancer treatment, for example, to follow tumor response to EBRT and dosimetry; both of them are important issues for the cancer centers. The main goal of this proposal is to explore the use of multi-wavelength photoacoustic imaging to follow the tumor's response to the EBRT. In addition, generating x-ray acoustic imaging during irradiation for dosimetry. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
NASER, MOHAMED A.; SAMPAIO, DIEGO R. T.; MUNOZ, NINA M.; WOOD, CAYLA A.; MITCHAM, TREVOR M.; STEFAN, WOLFGANG; SOKOLOV, KONSTANTIN V.; PAVAN, THEO Z.; AVRITSCHER, RONY; BOUCHARD, RICHARD R.. Improved Photoacoustic-Based Oxygen Saturation Estimation With SNR-Regularized Local Fluence Correction. IEEE TRANSACTIONS ON MEDICAL IMAGING, v. 38, n. 2, p. 561-571, . (16/22720-3)
WOOD, CAYLA A.; HAN, SANGHEON; KIM, CHANG SOO; WEN, YUNFEI; SAMPAIO, DIEGO R. T.; HARRIS, JUSTIN T.; HOMAN, KIMBERLY A.; SWAIN, JODY L.; EMELIANOV, STANISLAV Y.; SOOD, ANIL K.; et al. Clinically translatable quantitative molecular photoacoustic imaging with liposome-encapsulated ICG J-aggregates. NATURE COMMUNICATIONS, v. 12, n. 1, . (16/22720-3)

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