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Development of biopolymeric wafers for buccal administration of local anesthetics

Grant number: 17/06613-5
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2017
Effective date (End): June 30, 2018
Field of knowledge:Health Sciences - Pharmacy - Pharmaceutical Technology
Principal researcher:Laura de Oliveira Nascimento
Grantee:Karen de Oliveira Cruvinel
Home Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:14/14457-5 - Lipid-based nanocarriers (SLN/NLC and remote-loading liposomes) used to improve the upload and potency of local anesthetics, AP.TEM

Abstract

There are several medicines used as oral anesthetics available in the market, but they do not always achieve the necessary analgesia in cases of invasive dental procedures. Local anesthetics allow a reversible blockage of the conduction of nerve impulses, leading to no pain sensation, without affecting consciousness. Lidocaine is an important drug of this class, which was introduced to dental practice in the 1950s, presenting appropriate efficacy and safety characteristics, providing anesthetic effects of 1.5 to 3 hours when used intravenously. The release form of the drug to be studied is lyophilized wafers (relatively new formulations, developed from the lyophilization of polymer solutions or gels), which allow easy application of the resulting cake to the oral mucosa. It is intended to develop a lyophilized wafer in order to release the local anesthetic, such as lidocaine, for oral use, making use of a polymeric matrix as a base. The wafers that best behave may be used in future pre-clinical tests. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RIBEIRO COSTA, JULIANA SOUZA; CRUVINEL, KAREN DE OLIVEIRA; OLIVEIRA-NASCIMENTO, LAURA. A mini-review on drug delivery through wafer technology: Formulation and manufacturing of buccal and oral lyophilizates. JOURNAL OF ADVANCED RESEARCH, v. 20, p. 33-41, . (17/06613-5, 14/14457-5)

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