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Evaluation of additional therapies in patients with generalized aggressive periodontitis: treatment of residual pockets and regeneration of furcations defects: randomized-controlled clinical trial

Grant number: 16/15143-0
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): June 01, 2017
Effective date (End): April 30, 2019
Field of knowledge:Health Sciences - Dentistry - Periodontology
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Mauro Pedrine Santamaria
Grantee:Naira Maria Rebelatto Bechara Andere
Host Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Estadual Paulista (UNESP). Campus de São José dos Campos. São José dos Campos , SP, Brazil


The scaling and root planing (SRP) as a part of the non-surgical periodontal treatment is considerate as gold standart for the treatment of the periodontal disease. However, in some cases, such as in deep pockets or sites presenting proximal furcation, SRP may not be sufficient to dope with the periodontal infection. These situations may lead to periodontal pockets persistence - e.i. residual pockets. There are few studies that evaluate treatment protocols of residual pockets in patients presenting Generalized Aggressive Periodontitis (GAgP) who have already received some kind of therapeutic approach. Just few studies aimed to elucidate the periodontal regeneration process in these individuals, though. Thus, the aim of the present study is to evaluate additional therapy approaches in order to deal with two types conditions. The first part of the study aims to assess whether repeated applications of antimicrobial photodynamic therapy (APDT) are equivalent to surgical approach in the treatment of residual pockets of single-rooted teeth. The second part of this study aims to evaluate whether the use of enamel matrix derivative proteins (EMD) performs better than just surgical approach in the treatment of furcation defects on upper molars. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ANDERE, NAIRA M. R. B.; CASTRO DOS SANTOS, NIDIA C.; ARAUJO, CASSIA F.; PAZ, HELVIS E. S.; SHADDOX, LUCIANA M.; CASARIN, RENATO C., V; SANTAMARIA, MAURO P.. Open flap debridement compared to repeated applications of photodynamic therapy in the treatment of residual pockets: A randomized clinical trial. Journal of Periodontology, v. 93, n. 11, p. 11-pg., . (16/15143-0, 17/05101-0)
GONCALVES, BIANCA COSTA; FERREIRA COSTA, ANDRE LUIZ; CORREA, RAQUEL; REBELATTO BECHARA ANDERE, NAIRA MARIA; OGAWA, CELSO MASSAHIRO; SANTAMARIA, MAURO PEDRINE; PEREIRA DE CASTRO LOPES, SERGIO LUCIO. Analysis of geometrical tomographic parameters of furcation lesions in periodontitis patients. HELIYON, v. 7, n. 1, . (17/05101-0, 16/15143-0, 18/17850-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
ANDERE, Naira Maria Rebelatto Bechara. Avaliação de terapias adicionais em pacientes portadores de periodontite agressiva generalizada: tratamento de bolsas residuais e regeneração de lesões de bifurcações. Estudo clínico controlado randomizado. 2019. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Instituto de Ciência e Tecnologia. São José dos Campos São José dos Campos.

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