Advanced search
Start date
Betweenand

Effects of physical training in lipid content and insulin resistance in skeletal muscle of patients with idiopathic inflammatory myopathies: randomized controlled trial

Grant number: 16/19771-5
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): June 01, 2017
Effective date (End): May 31, 2020
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Samuel Katsuyuki Shinjo
Grantee:Diego Sales de Oliveira
Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Dermatomyositis (DM) and polymyositis (PM) are rare systemic idiopathic inflammatory myopathies associated with high morbidity and functional disability. DM/PM patients may show as clinical consequence, increased muscle atrophy/hypotrophy associated with decreased muscle oxidative capacity. In addition, our group showed for the first time that DM/PM patients have a high prevalence of metabolic syndrome. Insulin resistance (IR) is an important component of metabolic syndrome. Increase IR in skeletal muscle affects lipids oxidation in this territory, resulting in lipids accumulation. Physical training is an important tool to increase oxidative capacity and improve IR. Thus, this study aim to evaluate the effect of physical training in IR and lipid content in skeletal muscle of DM/PM patients. Due to muscle atrophy/hypotrophy and the decrease in oxidative capacity, which are characteristic of DM/PM patients, our hypothesis is that there is a decrease in fatty acid oxidation, resulting in intramuscular lipids accumulation in these patients. This accumulation can lead to IR which in turn would damage the lipid oxidation in skeletal muscle. Physical training improves oxidative capacity and increased muscle cross sectional area. Therefore, physical training could improve fatty acids oxidation and lead to insulin resistance attenuation by reducing insulin receptor substrate-1 (IRS-1) phosphorylation. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications (9)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE OLIVEIRA, DIEGO SALES; PIRES BORGES, ISABELA BRUNA; DE SOUZA, JEAN MARCOS; GUALANO, BRUNO; RODRIGUES PEREIRA, ROSA MARIA; SHINJO, SAMUEL KATSUYUKI. Exercise training attenuates insulin resistance and improves beta-cell function in patients with systemic autoimmune myopathies: a pilot study. CLINICAL RHEUMATOLOGY, v. 38, n. 12, p. 3435-3442, . (16/19771-5, 16/20371-1, 17/13109-1)
PIRES BORGES, ISABELA BRUNA; DE OLIVEIRA, DIEGO SALES; MISSE, RAFAEL GIOVANI; DOS SANTOS, ALEXANDRE MOURA; COSTA HONG, VALERIA APARECIDA; BORTOLOTTO, LUIZ APARECIDO; SHINJO, SAMUEL KATSUYUKI. Safety of Atorvastatin in Patients With Stable Systemic Autoimmune Myopathies A Pilot Longitudinal Study. JCR-JOURNAL OF CLINICAL RHEUMATOLOGY, v. 27, n. 6, p. S236-S241, . (16/19771-5, 16/23574-0, 18/08735-3, 17/13109-1, 16/20371-1)
LUIS CARLOS JACINTO; BRUNO TONICELLI TARTARINI FERNANDES; DIEGO SALES DE OLIVEIRA. Use of CMAP tools® software to teaching muscle contraction: an experience with undergraduates students in physical education. Motriz: rev. educ. fis., v. 25, n. 1, . (16/19771-5)
DE OLIVEIRA, DIEGO SALES; DE SOUZA, JEAN MARCOS; SHINJO, SAMUEL KATSUYUKI. Beyond medicine: Physical exercise should be always considered in patients with systemic autoimmune myopathies. AUTOIMMUNITY REVIEWS, v. 18, n. 3, p. 315-316, . (16/19771-5, 17/13109-1)
DE SOUZA, J. M.; DE OLIVEIRA, D. S.; PERIN, L. A.; MISSE, R. G.; DOS SANTOS, A. M.; GUALANO, B.; DE SA PINTO, A. L.; ROSCHEL, H.; LIMA, F. R.; SHINJO, S. K.. Feasibility, safety and efficacy of exercise training in immune-mediated necrotising myopathies: a quasi-experimental prospective study. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, v. 37, n. 2, p. 235-241, . (17/13109-1, 16/23574-0, 17/06794-0, 16/19771-5)
DIEGO SALES DE OLIVEIRA; MARILDA SILVA GUIMARÃES; SAMUEL KATSUYUKI SHINJO. RESISTÊNCIA INSULÍNICA AUMENTADA EM PACIENTES COM DERMATOMIOSITE. MedicalExpress (São Paulo, online), v. 5, . (16/19771-5, 12/07101-4)
PIRES BORGES, ISABELA BRUNA; DE OLIVEIRA, DIEGO SALES; NAGAHASHI MARIE, SUELY KAZUE; LENARIO, ANTONIO MARCONDES; OBA-SHINJO, SUELI MIEKO; SHINJO, SAMUEL KATSUYUKI. Exercise Training Attenuates Ubiquitin-Proteasome Pathway and Increases the Genes Related to Autophagy on the Skeletal Muscle of Patients With Inflammatory Myopathies. JCR-JOURNAL OF CLINICAL RHEUMATOLOGY, v. 27, n. 6, p. S224-S231, . (16/19771-5, 19/11367-9, 17/13109-1)
DIEGO SALES DE OLIVEIRA; LUCAS SERTORIO CARRASCOZA; NEY ROBSON DE ALMEIDA; LEANDRO CAMPOS DE BRITO; MARCELO MARQUES; LEANDRO SILVA ALVES; PATRICIA CHAKUR BRUM. Cardiovascular physiology and autonomic heart control principles: the use of a station rotation strategy to recall basic cardiovascular knowledge among exercise science students. Motriz: rev. educ. fis., v. 28, . (16/50336-3, 16/19771-5, 15/22814-5)
DE OLIVEIRA, DIEGO SALES; BORGES, ISABELA BRUNA PIRES; MARIE, SUELY KAZUE NAGAHASHI; LERARIO, ANTONIO MARCONDES; OBA-SHINJO, SUELI MIEKO; SHINJO, SAMUEL KATSUYUKI. Exercise training attenuates skeletal muscle fat infiltration and improves insulin pathway of patients with immune-mediated necrotizing myopathies and dermatomyositis. ARCHIVES OF RHEUMATOLOGY, v. 38, n. 2, p. 11-pg., . (19/11367-9, 16/19771-5, 17/13109-1)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
OLIVEIRA, Diego Sales de. Effects of exercise training on skeletal muscle lipid content and insulin resistance in patients with systemic autoimmune myopathies. 2020. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.

Please report errors in scientific publications list using this form.