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Identification/elucidation and validation of new targets/pathways involved in osteoarthritis

Grant number: 17/06736-0
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): June 01, 2017
Effective date (End): March 20, 2022
Field of knowledge:Biological Sciences - Immunology - Immunogenetics
Cooperation agreement: GlaxoSmithKline
Principal researcher:Olga Celia Martinez Ibanez
Grantee:Jean Gabriel de Souza
Home Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Associated research grant:15/50040-4 - Rational approach for searching molecular targets involved in inflammatory events and cell survival, AP.PCPE
Associated scholarship(s):19/20713-8 - The role of extracellular ASC in rheumatoid arthritis inflammation, BE.EP.PD

Abstract

The objective of the Centre of Excellence in New Target Discovery (CENTD) is to identify molecular targets involved in inflammatory events and cell survival, focusing in joint diseases (rheumatoid arthritis and osteoarthritis) and cancer, using protein fractions or peptides derived from animal toxins of different origins that are studied in a multidisciplinary way, by the several research groups of the Institute that participate in CENTD. The Immunogenetics Laboratory at Instituto Butantan participates in CENTD and is focused on the study of the genetic control of complex immune characters such as antibody levels and acute inflammatory response intensity. The experimental model is based in pairs of "High" and "low" responder mouse lines that were produced by successive generations of bi-directional selection for these phenotypes. Due to the selection process, profound modifications were also introduced in natural resistance of these lines to infections, in susceptibility to experimental arthritis and to the induction of tumors by chemical carcinogens. In the context of CENTD, the High and Low responder mice will be used as a model system for preclinical tests of the action of in vitro selected compounds in inflammatory joint diseases and cancer. Modern tools will be integrated for the follow-up of the treatment effect over the relevant phenotypes in the resistant and susceptible mice. (AU)

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