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A sustainable solution against neglected tropical diseases using biosurfactants produced by yeasts in sugarcane bagasse hemicellulosic hydrolyzate

Grant number: 16/14852-7
Support Opportunities:Scholarships in Brazil - Post-Doctorate
Effective date (Start): June 01, 2017
Effective date (End): May 31, 2022
Field of knowledge:Biological Sciences - Microbiology - Applied Microbiology
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Silvio Silvério da Silva
Grantee:Paulo Ricardo Franco Marcelino
Host Institution: Escola de Engenharia de Lorena (EEL). Universidade de São Paulo (USP). Lorena , SP, Brazil
Associated research grant:16/10636-8 - From the cell factory to the Biodiesel-Bioethanol integrated biorefinery: a systems approach applied to complex problems in micro and macroscales, AP.BIOEN.TEM
Associated scholarship(s):19/19757-0 - Evaluation of the interaction of soforolipid biosurfactant with phospholipid membrane models, BE.EP.PD


Brazil has experienced a moment of extreme attention in public health. Cases of dengue, zika and chikungunya have increased year after year, concerning both public health authorities and society. Recently, the fight against the Aedes aegypti mosquito has become the focus of several research groups and government advertisements, aiming at reducing the indexes related to the tropical diseases transmitted by it. Due to resistance mechanisms that A. aegypti exhibits to the larvicides and insecticides commonly used, it is necessary to develop new substances to be used in the control of this vector. Recently, some studies have shown the potential of microbial larvicide biosurfactants and essential plant oils. The strategy of using the biosurfactants and essential oils in larvicide formulations is extremely important for the national and world sustainable scenario. Besides being considered an important tool against A. aegypti and, consequently, the diseases transmitted by it, biosurfactants and essential plant oils are sustainable and environmentally benign products, are associated to green industrial processes and stimulate the concept of lignocellulosic biorefinery as a source of high value-added bio based products. Thus, this work aims to produce larvicide formulations based on biosurfactants, produced by yeast in culture medium supplemented with sugarcane bagasse hemicellulosic hydrolyzate, and orange essential oil. These raw materials are abundant in Brazil, and the characterization of these formulations will be an important step for the development of a technological and sustainable product to combat A. aegypti. (AU)

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Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FRANCO MARCELINO, PAULO RICARDO; DA SILVA, VINICIUS LUIZ; PHILIPPINI, RAFAEL RODRIGUES; VON ZUBEN, CLAUDIO JOSE; CONTIERO, JONAS; DOS SANTOS, JULIO CESAR; DA SILVA, SILVIO SILVERIO. Biosurfactants produced by Scheffersomyces stipitis cultured in sugarcane bagasse hydrolysate as new green larvicides for the control of Aedes aegypti, a vector of neglected tropical diseases. PLoS One, v. 12, n. 11, . (15/06238-4, 16/14852-7)
JIMENEZ, ITZCOATL M.; CHANDEL, ANUJ K.; MARCELINO, PAULO R. F.; ANJOS, VIRGILIO; COSTA, CASSIANO BATESTTIN; BELL, MARIA JOSE V.; PEREIRA, BARBARA; DA SILVA, SILVIO S.. Comparative data on effects of alkaline pretreatments and enzymatic hydrolysis on bioemulsifier production from sugarcane straw by Cutaneotrichosporon mucoides. Bioresource Technology, v. 301, . (16/10636-8, 08/57926-4, 16/14852-7)
ELIAS, ANDREW M.; LONGATI, ANDREZA A.; ELLAMLA, HARIKISHAN R.; FURLAN, FELIPE F.; RIBEIRO, MARCELO P. A.; MARCELINO, PAULO R. F.; DOS SANTOS, JULIO C.; DA SILVA, SILVIO S.; GIORDANO, ROBERTO C.. Techno-Economic-Environmental Analysis of Sophorolipid Biosurfactant Production from Sugarcane Bagasse. Industrial & Engineering Chemistry Research, v. 60, n. 27, p. 9833-9850, . (19/15851-2, 16/10636-8, 17/13349-2, 16/14852-7, 20/15450-5)
ASCENCIO, JESUS J.; PHILIPPINI, RAFAEL R.; GOMES, FABRICIO M.; PEREIRA, FELIX M.; DA SILVA, SILVIO S.; KUMAR, VINOD; CHANDEL, ANUJ K.. Comparative Highly Efficient Production of beta-glucan by Lasiodiplodia theobromae CCT 3966 and Its Multiscale Characterization. FERMENTATION-BASEL, v. 7, n. 3, . (16/10636-8, 16/14852-7, 14/18714-2, 08/57926-4)
MARCELINO, P. R. F.; PERES, G. F. D.; TERAN-HILARES, R.; PAGNOCCA, F. C.; ROSA, C. A.; LACERDA, T. M.; DOS SANTOS, J. C.; DA SILVA, S. S.. Biosurfactants production by yeasts using sugarcane bagasse hemicellulosic hydrolysate as new sustainable alternative for lignocellulosic biorefineries. INDUSTRIAL CROPS AND PRODUCTS, v. 129, p. 212-223, . (16/10636-8, 15/06238-4, 16/14852-7)
VIEIRA, MATHEUS MAITAN; KADOGUCHI, ELEN; SEGATO, FERNANDO; DA SILVA, SILVIO S.; CHANDEL, ANUJ K.. Production of cellulases byAureobasidium pullulansLB83: optimization, characterization, and hydrolytic potential for the production of cellulosic sugars. PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY, v. 51, n. 2, . (14/18714-2, 16/14852-7, 16/10636-8, 08/57926-4)
FERNANDA G. BARBOSA; DAYLIN R. RIBEAUX; THIAGO ROCHA; ROGGER A. M. COSTA; RAMIRO R. GUZMÁN; PAULO R. F. MARCELINO; TALITA M. LACERDA; SILVIO S. DA SILVA. Biosurfactants: Sustainable and Versatile Molecules. Journal of the Brazilian Chemical Society, v. 33, n. 8, p. 870-893, . (16/10636-8, 16/14852-7)

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