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Heterolog expression of putative xylose transporters from Candida sojae in Saccharomyces cerevisae aiming the 2G ethanol production

Grant number: 17/05078-9
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): June 01, 2017
Effective date (End): December 31, 2017
Field of knowledge:Biological Sciences - Genetics - Molecular Genetics and Genetics of Microorganisms
Principal Investigator:Leandro Vieira dos Santos
Grantee:João Gabriel Ribeiro Bueno
Host Institution: Centro Nacional de Pesquisa em Energia e Materiais (CNPEM). Ministério da Ciência, Tecnologia e Inovação (Brasil). Campinas , SP, Brazil


The world energy matrix is composed mainly of fossil compounds such as oil, gas and coal. However, in the past decades, the global community expressed great concern with the consequences of the intense use of these compounds, as the increase of greenhouse gases. Thus, alternatives for energy production as sustainable energy are needed. One of these possibilities, the second-generation ethanol (2G) produced from agricultural residues like straw and bagasse of sugar cane, emerge with a great potential for the future. The biggest challenge in the 2G technology implementation is the development of a robust microorganism capable of converting sugars from the lignocellulosic material in ethanol. The employed industrial strains of 1G ethanol industry do not have the capability to ferment 5-carbon sugars like xylose, present in abundance in lignocellulosic biomass. Many researchers made efforts to obtain yeasts capable to ferment xylose to ethanol. However, one of the limitations in xylose consume is its uptake, due to the low affinity of the sugar transporters to xylose. Thus, this project aims the prospection and characterization of four new putative xylose transporters from the yeast Candida sojae. The heterologous expression of a transporter that fasten xylose uptake rate of the cell will enable second generation strains to be used in the conversion of the sugars present in lignocellulosic hydrolysates in ethanol.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RIBEIRO BUENO, JOAO GABRIEL; BORELLI, GUILHERME; RIBEIRO CORREA, THAMY LIVIA; FIAMENGHI, MATEUS BERNABE; JOS, JULIANA; DE CARVALHO, MURILO; DE OLIVEIRA, LEANDRO CRISTANTE; PEREIRA, GONCALO A. G.; DOS SANTOS, LEANDRO VIEIRA. Novel xylose transporter Cs4130 expands the sugar uptake repertoire in recombinantSaccharomyces cerevisiaestrains at high xylose concentrations. BIOTECHNOLOGY FOR BIOFUELS, v. 13, n. 1, . (17/08519-6, 18/00888-5, 17/05078-9)

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