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Cellular and molecular aspects of the experimental ranavirosis in Nile tilapias (Oreochromis niloticus)

Grant number: 17/01718-3
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): June 01, 2017
Effective date (End): November 30, 2018
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Preventive Veterinary Medicine
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Ricardo Luiz Moro de Sousa
Grantee:Marcelo Candido
Host Institution: Faculdade de Zootecnia e Engenharia de Alimentos (FZEA). Universidade de São Paulo (USP). Pirassununga , SP, Brazil


Some pathologies associated with tilapia farming brings huge losses to farmers, resulting in significant rates of morbidity and mortality among animals of all ages. In this regard, requirements for the improvement of the laboratory diagnosis of infectious and contagious diseases became constant, given the economic, environmental and social losses associated. Among the major viral pathogens, showing worldwide distribution and recent history, Ranavirus stands out, and on which the studies in Brazil remain limited. The Ranavirus are viruses that infect ectothermic vertebrates causing widespread necrosis, focal hemorrhages and cellular apoptosis in infected animals. Detailed knowledge of the pathogenicity of this agent in tilapias is important for understanding the development and severity of the associated diseases, in view of the significant growth of the production of this fish in Brazil. In this sense, the main objective of this project is to accomplish experimental infections with Ranavirus in Nile tilapias (Oreochromis niloticus) for evaluation of the anatomopathological changes, viral load and immune response of the infected animals. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RUGGERI, JOICE; RIBEIRO, LUISA P.; PONTES, MARIANA R.; TOFFOLO, CARLOS; CANDIDO, MARCELO; CARRIERO, MATEUS M.; ZANELLA, NOELI; SOUSA, RICARDO L. M.; TOLEDO, LUIS FELIPE. Discovery of Wild Amphibians Infected with Ranavirus in Brazil. JOURNAL OF WILDLIFE DISEASES, v. 55, n. 4, p. 897-902, . (17/01917-6, 12/08846-3, 16/25358-3, 17/01718-3, 16/03344-0)
CANDIDO, MARCELO; TAVARES, LOIANE SAMPAIO; ALENCAR, ANNA LUIZA FARIAS; FERREIRA, CLAUDIA MARIS; DE ALMEIDA QUEIROZ, SABRINA RIBEIRO; FERNANDES, ANDREZZA MARIA; MORO DE SOUSA, RICARDO LUIZ. Genome analysis of Ranavirus frog virus 3 isolated from American Bullfrog (Lithobates catesbeianus) in South America. SCIENTIFIC REPORTS, v. 9, . (16/21357-2, 17/01718-3, 12/08846-3, 15/24590-7)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
CANDIDO, Marcelo. Cellular and molecular aspects of the experimental ranavirus infection in Nile tilapias (Oreochromis niloticus).. 2018. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Zootecnica e Engenharia de Alimentos (FZE/BT) Pirassununga.

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