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Bromelain encapsulation: characterization and stability

Grant number: 17/05333-9
Support Opportunities:Scholarships abroad - Research Internship - Scientific Initiation
Effective date (Start): August 31, 2017
Effective date (End): November 29, 2017
Field of knowledge:Health Sciences - Pharmacy
Principal Investigator:Priscila Gava Mazzola
Grantee:Eloah Favero Gérios
Supervisor: Eliana Maria Barbosa Souto
Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Research place: Universidade de Coimbra (UC), Portugal  
Associated to the scholarship:16/02282-1 - Stability and release study of encapsulated bromelain in chitosan nanoparticles, BP.IC

Abstract

Nanoparticles are carrier systems for organic compounds, which are considered promising for facilitating the bioavailability of these compounds in pharmaceutical forms, being used as a strategy to increase safety, efficacy and stability. Bromelain, in turn, is a protein found in pineapple (Bromeliaceae family), which has proteolytic, healing, anti-cancer, and anti-inflammatory activities, among others, being used in the pharmaceutical, food and textile industries. Bromelain encapsulation in order to improve its stability in pharmaceutical products is still unclear, so this project aims to study the stability of encapsulated bromelain under stress conditions, as well as the comparison of these with chitosan nanoparticles. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ATAIDE, JANAINA ARTEM; GERIOS, ELOAH FAVERO; MAZZOLA, PRISCILA GAVA; SOUTO, ELIANA B.. Bromelain-loaded nanoparticles: A comprehensive review of the state of the art. ADVANCES IN COLLOID AND INTERFACE SCIENCE, v. 254, p. 48-55, . (17/05333-9, 16/03444-5, 17/05275-9)
ATAIDE, JANAINA ARTEM; GERIOS, ELOAH FAVERO; CEFALI, LETICIA CARAMORI; FERNANDES, ANA RITA; TEIXEIRA, MARIA DO CEU; FERREIRA, NUNO R.; TAMBOURGI, ELIAS BASILE; JOZALA, ANGELA FAUSTINO; CHAUD, MARCO VINICIUS; OLIVEIRA-NASCIMENTO, LAURA; et al. Effect of Polysaccharide Sources on the Physicochemical Properties of Bromelain-Chitosan Nanoparticles. POLYMERS, v. 11, n. 10, . (17/05333-9, 16/03444-5, 17/05275-9)

Please report errors in scientific publications list using this form.

Filed patent(s) as a result of this research project

PROCESSO DE OBTENÇÃO DE UMA COMPOSIÇÃO LIOFILIZADA DE NANOPARTÍCULAS A BASE DE QUITOSANA CONTENDO BROMELINA, COMPOSIÇÃO LIOFILIZADA DE NANOPARTÍCULAS A BASE DE QUITOSANA CONTENDO BROMELINA E USO NO TRATAMENTO DE FERIDAS PCT/BR2020/050256 - Universidade Estadual de Campinas (UNICAMP) . Janaína Artem Ataíde ; Danilo Costa Geraldes ; Laura de Oliveira Nascimento ; Priscila Gava Mazzola - July 2020, 13