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Influence of periodontal treatment on the levels of oral inflammatory markers in HIV-infected patients

Grant number: 16/22476-5
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): June 01, 2017
Effective date (End): December 31, 2017
Field of knowledge:Health Sciences - Dentistry
Principal Investigator:Ana Carolina Fragoso Motta
Grantee:Vanessa de Oliveira Teles
Host Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Chronic periodontitis affects more severity and frequency of immunosuppressed patients, including HIV-infected patients. The immunosuppression caused by HIV infection may, in part, explain the lower efficiency of periodontal therapy in these patients, however, the expression of certain inflammatory mediators can also be associated with increased severity of chronic periodontal disease in these patients. The aim of this study is to assess whether periodontal treatment can alter the concentrations of salivary cytokines (Lf, IL-1beta, TNF-alpha, IL-6) in patients infected and HIV-uninfected, correlating these possible changes with improvement clinical periodontal disease by means of an almost experimental study. Participate in this study 20 patients infected with HIV and 20 HIV-non infected participants, all with chronic periodontitis, which will be submitted to periodontal therapy. The levels of biomarkers in saliva and gingival crevicular fluid will be evaluated before and after periodontal treatment by ELISA. In order to minimize the influence of immune-compromised patients infected with HIV, only participants will be selected with LTCD-4 count <200cel / mm 3, viral load undetectable, and regular use of antiretroviral therapy. This study was approved by the Institutional Review Board of the FORP/USP (CAAE: 50004415.1.0000.5419), and all patients must give informed consent.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
NOBRE, ATILA V. V.; POLVORA, TABATA L. S.; SILVA, LETICIA R. M.; TELES, VANESSA DE O.; VILLAFUERTE, KELLY VARGAS; DA MOTTA, RAPHAEL J. G.; FORTES, JOAO H. P.; SILVA, GILBERTO A.; RANIERI, ANA LAURA P.; DE MACEDO, LEANDRO D.; et al. Effects of non-surgical periodontal therapy on clinical and immunological profile and oral colonization of Candida spp in HIV-infected patients with chronic periodontitis. Journal of Periodontology, v. 90, n. 2, p. 167-176, . (16/22476-5)
POLVORA, TABATA LARISSA S.; NOBRE, ATILA VINICIUS V.; TIRAPELLI, CAMILA; TABA, JR., MARIO; DE MACEDO, LEANDRO DORIGAN; SANTANA, RODRIGO CARVALHO; POZZETTO, BRUNO; LOURENCO, ALAN GRUPIONI; MOTTA, ANA CAROLINA F.. Relationship between human immunodeficiency virus (HIV-1) infection and chronic periodontitis. EXPERT REVIEW OF CLINICAL IMMUNOLOGY, v. 14, n. 4, p. 315-327, . (10/18246-8, 16/22476-5)
RAMOS PENA, DIANA ESTEFANIA; ALENCAR RAMOS INNOCENTINI, LARA MARIA; PEREIRA SARAIVA, MARIA CONCEICAO; LOURENCO, ALAN GRUPIONI; FRAGOSO MOTTA, ANA CAROLINA. Oral candidiasis prevalence in human immunodeficiency virus-1 and pulmonary tuberculosis coinfection: A systematic review and meta-analysis. Microbial Pathogenesis, v. 150, . (16/22476-5)

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