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Bromelain encapsulation: stability, release profile, and cytotoxicity

Grant number: 17/05275-9
Support type:Scholarships abroad - Research Internship - Master's degree
Effective date (Start): July 14, 2017
Effective date (End): November 13, 2017
Field of knowledge:Health Sciences - Pharmacy
Principal researcher:Priscila Gava Mazzola
Grantee:Janaína Artem Ataide
Supervisor abroad: Eliana Maria Barbosa Souto
Home Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Research place: Universidade de Coimbra (UC), Portugal  


Bromelain is a collective name for proteolytic enzymes found in species of the Bromeliaceae family, mainly on the stem, fruit and leaves of pineapple (Ananas comosus). The use of this enzyme is highlighted in the food, cosmetic and mainly pharmaceutical industries due to its proteolytic activity. As an enzyme, bromelain use has limitations, since it is easily denatured and degraded, in addition to being unstable in some formulations. A possible alternative to better explore bromelain potential is its encapsulation in nanoparticles. These systems are capable of providing greater stability, efficacy and safety for the encapsulated active and have attracted the interest of the pharmaceutical industry. In this scenatio, chitosan emerges as a promising polymer, mainly due to the biocompatible, biodegradable and mucoadhesive characteristics. This project aims to characterize chitosan-bromelain nanoparticles, as well as to evaluate their release profile and their cytotoxicity in cell lines, with the ultimate goal of making bromelain use viable in formulations.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ATAIDE, JANAINA ARTEM; GERIOS, ELOAH FAVERO; MAZZOLA, PRISCILA GAVA; SOUTO, ELIANA B.. Bromelain-loaded nanoparticles: A comprehensive review of the state of the art. ADVANCES IN COLLOID AND INTERFACE SCIENCE, v. 254, p. 48-55, . (16/03444-5, 17/05333-9, 17/05275-9)
FRANCO, JULIA GOMES; CEFALI, LETICIA CARAMORI; ATAIDE, JANAINA ARTEM; SANTINI, ANTONELLO; SOUTO, ELIANA B.; MAZZOLA, PRISCILA GAVA. Effect of nanoencapsulation of blueberry (Vaccinium myrtillus): A green source of flavonoids with antioxidant and photoprotective properties. SUSTAINABLE CHEMISTRY AND PHARMACY, v. 23, . (15/25533-7, 17/14757-7, 17/05275-9)
ATAIDE, JANAINA ARTEM; GERIOS, ELOAH FAVERO; CEFALI, LETICIA CARAMORI; FERNANDES, ANA RITA; TEIXEIRA, MARIA DO CEU; FERREIRA, NUNO R.; TAMBOURGI, ELIAS BASILE; JOZALA, ANGELA FAUSTINO; CHAUD, MARCO VINICIUS; OLIVEIRA-NASCIMENTO, LAURA; et al. Effect of Polysaccharide Sources on the Physicochemical Properties of Bromelain-Chitosan Nanoparticles. POLYMERS, v. 11, n. 10, . (16/03444-5, 17/05333-9, 17/05275-9)

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