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Seasonal variation of the chemical composition and antioxidant activity extracts of leaves of Maytenus ilicifolia Mart. ex Reiss, Maytenus aquifolium Mart (Celastraceae) and their hybrids

Grant number: 17/00155-5
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): May 01, 2017
Effective date (End): February 28, 2019
Field of knowledge:Health Sciences - Pharmacy - Pharmacognosy
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Alexandra Christine Helena Frankland Sawaya
Grantee:Elisa Ribeiro Miranda Antunes
Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


The species, Maytenus ilicifolia and Maytenus aquifolium, popularly known as "Espinheira Santa", are widely used in traditional Brazilian medicine to treat gastrites and digestive problems. Several studies have shown that these species have gastro protective and anti-ulcer activity, which may be related to their antioxidant properties. According to some studies, the increased production of reactive species of oxygen and nitrogen cause serious cellular alterations, characterizing oxidative stress. When the antioxidant defensive system is reduced or hindered, this may lead to stress-related pathogenic lesions of the gastric mucosa. However, to obtain a high-quality phytotherapic medicine and propose criteria for standardization, it is necessary to know the chemical variability of the plant species used as the raw material. Only one study was found reporting the seasonal fluctuations in the chemical composition of the Maytenus genus. The purpose of the present study is to identify possible seasonal variations in the chemical composition of the extracts of these two species and their hybrids, in order to indicate the best season for their harvest, to obtain standardized phytotherapic medicine for the treatment of gastric disorders. In this way, the leaves of five individuals of M. ilifolia, five of M. aquifolium and five of their hybrids, will be collected once a month over one year. Their extracts will be analyzed via ultra-high performance liquid chromatography with mass spectrometry (UHPLC-MS, as well as their antioxidant activity determined by DPPH and ORAC tests. Finally the data of composition and activity will be correlated to identify those whose extracts present higher activity. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MIRANDA ANTUNES, ELISA RIBEIRO; DUARTE, RODOLFO SANTOS; MORITZ, THOMAS; HELENA FRANKLAND SAWAYA, ALEXANDRA CHRISTINE. Differentiation of two Maytenus species and their hybrid via untargeted metabolomics. INDUSTRIAL CROPS AND PRODUCTS, v. 158, . (17/00155-5)
DUARTE, RODOLFO SANTOS; MIRANDA ANTUNES, ELISA RIBEIRO; HELENA FRANKLAND SAWAYA, ALEXANDRA CHRISTINE. Simultaneous UHPLC-MS Quantification of Catechins and Untargeted Metabolomic Profiling for Proof-of-Concept Authenticity Determination of Maytenus ssp. Samples. Molecules, v. 27, n. 17, p. 9-pg., . (17/00155-5)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
ANTUNES, Elisa Ribeiro Miranda. Seasonal variation of the chemical composition and antioxidant activity of leaf extracts of Maytenus ilicifolia Mart. ex Reiss, Maytenus aquifolium Mart. (Celastraceae) and their hybrid. 2019. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia Campinas, SP.

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