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Evaluation of the effects of ivermectin administered in childhood period in sexual behavior of rats adults

Grant number: 17/00020-2
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): April 01, 2017
Effective date (End): December 31, 2017
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Pathology
Principal Investigator:Helenice de Souza Spinosa
Grantee:Fernanda Lemes Vicente
Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Ivermectin is a macrocyclic lactone used in the treatment of parasitic infections in humans and widely used in veterinary medicine as endectocide. In mammals, several evidences indicate that interact with the macrocyclic lactones chloride channels mediated by gamma-aminobutyric acid (GABA). It is known that the GABAergic system is involved in the manifestation of sexual behavior. Previous studies from our group about the behavioral effects of acute administration of macrocyclic lactones showed impairment in sexual behavior in rats, and these effects associated with the central GABAergic system. Recently, another study in our group, noted that ivermectin administration in rats reduced testosterone levels without interfering with sexual motivation and penile erection males, while in females impaired sexual behavior. Thus, continuing our studies and to contribute to the understanding of the physiological and pharmacological mechanisms involved in the effects of ivermectin in the reproductive sphere, the present project aims to evaluate the effects of administration of 0.2 mg/kg of ivermectin, orally, in the sexual behavior of adult rats treated during childhood. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MOREIRA, N.; VICENTE, F. L.; SANDINI, T. M.; MARTINELLI, E. C. L.; NAVAS-SUAREZ, P. E.; REIS-SILVA, T. M.; SPINOSA, H. S.. Effects of ivermectin treatment during prepubertal and pubertal period on sexual parameters and sexual behavior in adulthood in rats. Research in Veterinary Science, v. 129, p. 21-27, . (17/00020-2, 15/03131-4)

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