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Comparative study of the abamectin and difenoconazole toxic effects in embryos and adults of Danio rerio

Grant number: 17/05543-3
Support Opportunities:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): June 05, 2017
Effective date (End): October 04, 2017
Field of knowledge:Biological Sciences - Biochemistry - Metabolism and Bioenergetics
Principal Investigator:Evaldo Luiz Gaeta Espindola
Grantee:Ana Letícia Madeira Sanches
Supervisor: Paula Ines Borralho Domingues
Host Institution: Escola de Engenharia de São Carlos (EESC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
Research place: Universidade de Aveiro (UA), Portugal  
Associated to the scholarship:14/14621-0 - Analysis of the environmental effects of Kraft and score pesticides and its active ingredients abamectin and difenoconazole in tropical surface waters by biomarkers, BP.DR


There are many agrochemicals used in agriculture among them Kraft 36EC® which has abamectin as its active ingredient and Score 250EC®, active ingredient diphenoconazole. They are compounds widely used in strawberry crops in regions of tropical climate, and despite that they are classified as extremely toxic and very dangerous to the environment. The use of the fish as test organisms stands out in ecotoxicology due to their representative importance and critical role in aquatic food webs. Due to ethical issues and in order to reduce costs, space and waste generated, alternative methods using fish embryos are currently widely used. FET - Fish Embryo Toxicity Test already has many followers, but the sensitivity of this test, compared to adult organisms, is often questioned. Studies show that the sensitivity of the different stages of life of the Danio rerio depends on the characteristics of the compounds and their interactions. Little is known about the causes of sensitivity differences between the life stages of an organism, and to better understand the toxicokinetics of the different compounds, it is recommended that the toxicity of the chemicals be tested on embryos, juveniles and / or adults. Considering the ecological risks inherent to the use of the insecticide abamectin and the fungicide difenoconazole, the main objective of this research is to evaluate the effect generated in Danio rerio embryos exposed to isolated pesticides and in mixtures, and to compare these results by means of statistical correlations with the sensitivity of tests previously performed using adults of Danio rerio.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MEIRELES, GABRIELA; DAAM, MICHIEL A.; MADEIRA SANCHES, ANA LETICIA; ZANONI, MARIA V. B.; SOARES, AMADEU M. V. M.; GRAVATO, CARLOS; DE OLIVEIRA, DANIELLE P.. Red disperse dyes (DR 60, DR 73 and DR 78) at environmentally realistic concentrations impact biochemical profile of early life stages of zebrafish (Danio rerio). Chemico-Biological Interactions, v. 292, p. 94-100, . (17/05543-3, 14/14621-0, 16/03281-9)
MADEIRA SANCHES, ANA LETICIA; DAAM, MICHIEL ADRIAAN; FREITAS, EMANUELA CRISTINA; GODOY, ALINE ANDRADE; MEIRELES, GABRIELA; ALMEIDA, ANA RITA; DOMINGUES, INES; GAETA ESPINDOLA, EVALDO LUIZ. Lethal and sublethal toxicity of abamectin and difenoconazole (individually and in mixture) to early life stages of zebrafish. Chemosphere, v. 210, p. 531-538, . (17/05543-3, 14/14621-0)

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