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Development and application of calcium phosphate nanoparticles functionalized with acidic monomers for dental remineralization

Grant number: 16/25971-7
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): April 01, 2017
Effective date (End): March 31, 2019
Field of knowledge:Health Sciences - Dentistry - Dental Materials
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Roberto Ruggiero Braga
Grantee:Marina Damasceno e Souza de Carvalho Chiari
Host Institution: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):18/02403-9 - Effect on bond strength and collagen degradation of experimental dentin adhesives containing calcium orthophosphate particles, BE.EP.MS


Calcium phosphate nanoparticles functionalization with ethylene glycol dimethacrylate derivatives is proved to be effective in reducing the negative effects of addition of calcium phosphate nanoparticles over the mechanical properties of resin composites. However, there were no significant reductions in the nanoparticle agglomeration. This project aims to: 1) investigate the effect of functionalization with different organic agents on the characteristics of CaP nanoparticles; 2) evaluate experimental composites containing these particles in relation to mechanical properties, degree of conversion, release of Ca2 + ions and HPO42- and their protective effect, in vitro, on the enamel adjacent to restorations in specimens submitted to a acid challenge. Data will be subjected to either one-way ANOVA (degree of conversion, mechanical properties and microhardness after acidic challenge) or two-way ANOVA (ion release). In all cases, Tukey test will be used for pair-wise comparisons. The global significance level (±) will be set at 5%. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CHIARI, MARINA D. S.; RODRIGUES, MARCELA C.; PINTO, MIRELLA F. C.; VIEIRA, DOUGLAS N.; VICHI, FLAVIO M.; VEGA, OSCAR; CHRZANOWSKI, WOJCIECH; NAGAOKA, NORIYUKI; BRAGA, ROBERTO R.. Development of brushite particles synthesized in the presence of acidic monomers for dental applications. Materials Science & Engineering C-Materials for Biological Applications, v. 116, . (17/06446-1, 16/50321-6, 16/25971-7)
VILELA, HANDIALLY S.; CAMPOS, AMANDA L.; CABRAL, CAMILA; CHIARI, MARINA D. S.; VIEIRA, DOUGLAS N.; BRAGA, ROBERTO R.. Effect of calcium orthophosphate: Reinforcing glass ratio and prolonged water storage on flexural properties of remineralizing composites. JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, v. 104, . (16/25971-7)
CHIARI, MARINA D. S.; ALANIA, YVETTE; BEDRAN-RUSSO, ANA K.; BRAGA, ROBERTO R.. Experimental dentin adhesives containing calcium orthophosphate particles: Effect on dentin bond strength, micro-permeability and collagen degradation. INTERNATIONAL JOURNAL OF ADHESION AND ADHESIVES, v. 107, . (16/25971-7, 18/02403-9)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
CHIARI, Marina Damasceno e Souza de Carvalho. Development and application of calcium phosphate particles functionalized with acidic monomers for dental remineralization. 2019. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Odontologia (FO/SDO) São Paulo.

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