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Genomic wide association study for feed efficiency traits in Nellore cattle breeding programs

Grant number: 16/24228-9
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): March 01, 2017
Effective date (End): July 31, 2018
Field of knowledge:Biological Sciences - Genetics - Animal Genetics
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Lucia Galvão de Albuquerque
Grantee:Samuel Wallace Boer dos Santos
Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil
Associated research grant:09/16118-5 - Genomic tools to genetic improvement of direct economic important traits in Nelore cattle, AP.TEM
Associated scholarship(s):17/13411-0 - Evaluation of benefits in combining two Nelore populations for genomic selection, BE.EP.MS


Feed efficiency traits are directly associated with beef cattle profitability and sustainability. Weight gain, feed consumption, conversion rate and residual feed intake (RFI), for example, are important traits for the selection of efficient animals within the production system, however, with the exception of weight gain, these traits are not considered as selection criteria due to the difficulty in obtaining phenotypes for the same animals. Currently, with the advance of sequencing and genotyping technologies, high-density SNP chips are available on market. These molecular information can be used for genome-wide association studies (GWAS), which allow the identification of genetic variants associated with the trait expression in different populations. Therefore, this project aims to conduct a genome-wide association study for feed efficiency, feed intake, weight gain, residual feed intake, and feed conversion rate in two Nelore populations belonging to two breeding programs: Instituto de Zootecnia (Sertãozinho/SP), and Nelore Qualitas . This project may detect chromosomal regions that are associated with the evaluated traits, aiming to find possible differences or similarities between the populations, and also to evaluate the existence of common candidate genes in both herds. The animals will be challenged in an individual performance test and evaluated for at least 70 days for feed consumption, weight gain, RFI and feed conversion rate. At the end of the test in 2016, we expecte to have a total of 1840 genotyped animals with phenotypic information. The consistency analysis will be performed for each trait, and the variance components will be estimated by using the Single-Step methodology. The animal model will include the fixed effect of contemporary group, fitting the genetic additive direct and residual effects as random. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MOTA, LUCIO F. M.; SANTOS, SAMUEL W. B.; JUNIOR, GERARDO A. FERNANDES; BRESOLIN, TIAGO; MERCADANTE, MARIA E. Z.; SILVA, JOSINEUDSON A. V.; CYRILLO, JOSLAINE N. S. G.; MONTEIRO, FABIO M.; CARVALHEIRO, ROBERTO; ALBUQUERQUE, LUCIA G.. Meta-analysis across Nellore cattle populations identifies common metabolic mechanisms that regulate feed efficiency-related traits. BMC Genomics, v. 23, n. 1, p. 12-pg., . (09/16118-5, 17/10630-2, 17/13411-0, 16/24228-9)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SANTOS, Samuel Wallace Boer dos. Genomic studies of feed efficiency traits in two Nelore populations. 2018. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Ciências Agrárias e Veterinárias. Jaboticabal Jaboticabal.

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