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Association of the empirical dietary inflammatory index (EDII) and single nucleotide polymorphisms in inflammatory genes with a systemic inflammatory pattern in a population-based study

Grant number: 17/00547-0
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): August 01, 2017
Effective date (End): February 28, 2018
Field of knowledge:Health Sciences - Nutrition - Nutritional Analysis of Population
Principal researcher:Marcelo Macedo Rogero
Grantee:Marina Maintinguer Norde
Supervisor abroad: Edward Giovannucci
Home Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Research place: Harvard University, Cambridge, United States  
Associated to the scholarship:16/03803-5 - Association of dietary patterns and single nucleotide plymorphisms in the genes of adiponectin, Toll like receptor-4, IL-1², IL-6, IL-10, TNF-±, CCL-2 and C reactive protein with a systemic inflammatory pattern at a population-based study - ISA-Capital, BP.DR


Experimental, epidemiological and clinical evidences point to a pathogenic role of inflammation on metabolic disorders development, being the dietary pattern an important risk factor for systemic low-grade inflammation. The empirical dietary inflammatory index (EDII) is a hypothesis-driven dietary pattern that can be applied in a standardized manner across different populations and has been associated with plasma inflammatory biomarkers concentration. Single Nucleotide Polymorphisms (SNP) can modulate the relationship between diet and plasma inflammatory biomarkers levels. Objective: To investigate the association between the EDII and systemic low-grade inflammation, as well as the interaction between EDII and SNP in the genes of adiponectin, Toll like receptor (TLR)-4, IL-1², IL-6, IL-10, tumor necrosis factor (TNF)-±, Chemokine C-C motif ligand (CCL)-2 and C reactive protein (CRP) at a population-based study - ISA-Capital. Methods: This study sample will be composed by adults (19 to 59 years), participants of the cross-sectional population-based Health Survey of Sao Paulo 2008-2010 (n=302). Dietary data have been collected using two non-consecutive 24 hours dietary recall, including the four seasons of the year and all the seven weekdays. Plasma concentration of adiponectin, CRP, IL-1², IL-6, IL-8, IL-10, TNF-±, IL-12p70, CCL-2, soluble intercellular adhesion molecule (sICAM)-1 and soluble vascular cell adhesion molecule (sVCAM)-1 was determined by multiplex immunoassay. SNP from adiponectin (rs266729, rs17300539, rs16861209, rs1501299 e rs2241766), TLR4 (rs4986790, rs4686791, rs5030728, rs11536889), IL-1² (rs1143623, rs16944, rs1143627, rs1143634 e rs1143643) and IL-6 (rs1800795, rs1800796, rs1800797), IL-10 (rs1800871, rs1800872, rs1800896, rs3024490, rs1554286), TNF-± (rs1799964, rs 1799724, rs1800629, rs361525), CCL-2 (rs1024611) and CRP (rs1205, rs1417938, rs2808630) gene were genotyped by Taqman Open Array system. The EDII will be calculated using the data of usual intake of eighteen food groups. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
NORDE, MARINA M.; COLLESE, TATIANA S.; GIOVANNUCCI, EDWARD; ROGERO, MARCELO M.. posteriori dietary patterns and their association with systemic low-grade inflammation in adults: a systematic review and meta-analysi. NUTRITION REVIEWS, v. 79, n. 3, p. 331-350, . (16/13922-1, 16/03803-5, 17/00547-0)
COLLESE, TATIANA S.; NORDE, MARINA M.; NASCIMENTO-FERREIRA, V, MARCUS; KIM, HANSEUL; MARCHIONI, DIRCE M.; CARVALHO, HERACLITO B.; GIOVANNUCCI, EDWARD. Which blood cutoff value should be used for vitamin A deficiency in children aged 3-10 years? A systematic review. NUTRITION REVIEWS, v. 79, n. 7, p. 777-787, . (19/13620-3, 16/13922-1, 17/00547-0, 16/03803-5)

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