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Validating siRNA silence and specificity for myosin expressed in macrophages

Grant number: 17/01313-3
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): March 01, 2017
Effective date (End): December 31, 2017
Field of knowledge:Biological Sciences - Immunology - Cellular Immunology
Principal researcher:Bruna Cunha Gondim de Alencar
Grantee:Letícia Kogachi
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:14/23225-0 - Role of myosins in dendritic cell mediated trans-infection of HIV-1 and in HIV-1 replication in macrophages, AP.JP

Abstract

Macrophages are considered important reservoirs for the HIV-1 virus. Several pieces of evidence point to the participation of the actin cytoskeleton in the replication of HIV-1 in macrophages. In spite of that, not much is known about motor proteins, including myosins, in the HIV-1 cycle. In order to implement the study of the participation of cellular myosins in HIV replication, they will be silenced using siRNAs. This project aims to confirm the expression of myosins on macrophages and find two siRNA sequences that silence each expressed myosin. (AU)

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